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肾移植术后一年患者的眼部病变

Eye Lesions in Patients After One Year of Kidney Transplantation.

作者信息

Trung Nguyen Le, Toan Pham Quoc, Trung Nguyen Kien, Tuan Vu Anh, Huyen Nguyen Thu

机构信息

Vietnam Department of Ophthalmology, Hanoi Medical University, Hanoi, Vietnam.

Vietnam Department of Ophthalmology, Military Hospital 103, Hanoi, Vietnam.

出版信息

Clin Ophthalmol. 2023 Sep 29;17:2861-2869. doi: 10.2147/OPTH.S424883. eCollection 2023.

Abstract

PURPOSE

Determine the incidence of some eye lesions in kidney transplant patients after one year at Military Hospital 103 and comment on related factors.

PATIENTS AND METHODS

A cross-sectional study description of 111 kidney transplant patients (222 eyes) at Military Hospital 103. We assessed several eye lesions, including dry eyes, corneal conjunctival calcification, cataracts, and retinopathy.

RESULTS

The rate of retinopathy was 84.7%, dry eye was 59.5%, cataract was 29.7%, and corneal conjunctival calcification was 24.8%, atrophy optic nerve was 9.9%, epiretinal membrane was 1.8%. Post-transplant influence factors associated with cataracts include the dose of prednisolone (OR= 1.6, p < 0.05) and post-transplant diabetes (OR=1.4, p < 0.05). The influence factor related to the atrophy of the optic nerve is systemic infection after transplantation (OR=2.4, p < 0.05).

CONCLUSION

Retinopathy accounted for the highest rate, followed by dry eye disease; cataracts ranked third; and finally, calcified corneal conjunctiva. Factors that affect cataracts are diabetes mellitus and prednisolone dose. Factors affecting optic nerve atrophy are infections after kidney transplantation.

摘要

目的

确定103军事医院肾移植患者术后一年某些眼部病变的发生率,并对相关因素进行评述。

患者与方法

对103军事医院的111例肾移植患者(222只眼)进行横断面研究描述。我们评估了几种眼部病变,包括干眼症、角膜结膜钙化、白内障和视网膜病变。

结果

视网膜病变发生率为84.7%,干眼症为59.5%,白内障为29.7%,角膜结膜钙化为24.8%,视神经萎缩为9.9%,视网膜前膜为1.8%。与白内障相关的移植后影响因素包括泼尼松龙剂量(OR = 1.6,p < 0.05)和移植后糖尿病(OR = 1.4,p < 0.05)。与视神经萎缩相关的影响因素是移植后全身感染(OR = 2.4,p < 0.05)。

结论

视网膜病变发生率最高,其次是干眼症;白内障排第三;最后是角膜结膜钙化。影响白内障的因素是糖尿病和泼尼松龙剂量。影响视神经萎缩的因素是肾移植后的感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b9c/10547587/2c0c630fbd70/OPTH-17-2861-g0001.jpg

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