Zheng Zhen, Li Xiao, Chen Guoqiang, Chen Jing, Zhu Xiaolu, Teng Yincheng
Department of Obstetrics and Gynecology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Obstetrics and Gynecology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Front Cell Dev Biol. 2023 Sep 20;11:1109710. doi: 10.3389/fcell.2023.1109710. eCollection 2023.
Perineural invasion (PNI) is a pathological feature of many cancers associated with poor outcomes, metastases, and recurrence. In relation to ovarian cancer (OC), there is no information about PNI's role and mechanisms. Our study found that patients with PNI-positive symptoms had significantly shorter overall survival (OS) time than patients with PNI-negative symptoms. Multivariate analyses demonstrated that PNI represented a substantial independent prognostic factor in OC patients. At the transcriptome level, it is noteworthy that PNI positivity was negatively correlated with the degree of infiltration of immune killer cells in OC tumor tissues, including macrophage, central memory CD4 T-cell, natural killer cells, monocyte, and central memory CD4 T-cell. The results of this study revealed that TAS2Rs proteins were markedly upregulated in PNI-positive OC tissues and predicted poor prognoses. Moreover, Immunohistochemical analysis demonstrated that the TAS2R10 protein was associated with poor prognoses and PNI in OC. Consequently, we found for the first time that PNI was a powerful predictor of poor prognosis in OC and analyzed its expression pattern and some preliminary biochemical characterization, providing new clues for guiding clinical prevention and treatment of OC.
神经周围浸润（PNI）是许多癌症的一种病理特征，与不良预后、转移和复发相关。关于卵巢癌（OC），目前尚无关于PNI作用和机制的信息。我们的研究发现，有PNI阳性症状的患者总生存（OS）时间显著短于PNI阴性症状的患者。多变量分析表明，PNI是OC患者的一个重要独立预后因素。在转录组水平上，值得注意的是，PNI阳性与OC肿瘤组织中免疫杀伤细胞的浸润程度呈负相关，这些免疫杀伤细胞包括巨噬细胞、中枢记忆CD4 T细胞、自然杀伤细胞、单核细胞和中枢记忆CD4 T细胞。本研究结果显示，TAS2Rs蛋白在PNI阳性的OC组织中显著上调，并预示着不良预后。此外，免疫组化分析表明，TAS2R10蛋白与OC的不良预后和PNI相关。因此，我们首次发现PNI是OC预后不良的有力预测指标，并分析了其表达模式和一些初步的生化特征，为指导OC的临床防治提供了新线索。
