Chen Guoqiang, Sun Hao, Chen Yunxia, Wang Li, Song Ouyi, Zhang Jili, Li Dazhi, Liu Xiaojun, Feng Lixia
Department of Obstetrics and Gynecology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.
Department of Gynecology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China.
Diagnostics (Basel). 2024 Jul 14;14(14):1517. doi: 10.3390/diagnostics14141517.
Perineural invasion (PNI), the neoplastic invasion of nerves, is an often overlooked pathological phenomenon in cervical cancer that is associated with poor clinical outcomes. The occurrence of PNI in cervical cancer patients has limited the promotion of Type C1 surgery. Preoperative prediction of the PNI can help identify suitable patients for Type C1 surgery. However, there is a lack of appropriate preoperative diagnostic methods for PNI, and its pathogenesis remains largely unknown. Here, we dissect the neural innervation of the cervix, analyze the molecular mechanisms underlying the occurrence of PNI, and explore suitable preoperative diagnostic methods for PNI to advance the identification and treatment of this ominous cancer phenotype.
神经周围浸润（PNI），即肿瘤对神经的浸润，是宫颈癌中一种常被忽视的病理现象，与不良临床预后相关。宫颈癌患者中PNI的发生限制了C1型手术的推广。术前预测PNI有助于识别适合C1型手术的患者。然而，目前缺乏针对PNI的合适术前诊断方法，其发病机制也 largely未知。在此，我们剖析子宫颈的神经支配，分析PNI发生的分子机制，并探索适合PNI的术前诊断方法，以推进对这种不祥癌症表型的识别和治疗。
