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Flavor of Iron at EHA2023: Novel Regulatory Mechanisms and Therapeutic Options for the Correction of Anemia.

作者信息

Vinchi Francesca, Asperti Michela, Marques Oriana, Nai Antonella, Silvestri Laura

机构信息

Iron Research Program, Lindsley Kimball Research Institute, New York Blood Center, New York City, NY, USA.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York City, NY, USA.

出版信息

Hemasphere. 2023 Oct 3;7(10):e955. doi: 10.1097/HS9.0000000000000955. eCollection 2023 Oct.

DOI:10.1097/HS9.0000000000000955
PMID:37799346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10550016/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91a3/10550016/9da12cf2edf4/hs9-7-e955-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91a3/10550016/9da12cf2edf4/hs9-7-e955-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91a3/10550016/9da12cf2edf4/hs9-7-e955-g001.jpg

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本文引用的文献

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FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes.FKBP12 通过调节肝细胞中 BMP 受体相互作用和配体反应性来抑制铁调素的表达。
Am J Hematol. 2023 Aug;98(8):1223-1235. doi: 10.1002/ajh.26961. Epub 2023 May 18.
2
A single approach to targeting transferrin receptor 2 corrects iron and erythropoietic defects in murine models of anemia of inflammation and chronic kidney disease.单一的转铁蛋白受体 2 靶向方法可纠正炎症性贫血和慢性肾脏病小鼠模型中的铁和红细胞生成缺陷。
Kidney Int. 2023 Jul;104(1):61-73. doi: 10.1016/j.kint.2023.03.012. Epub 2023 Mar 27.
3
Macrophage metabolic rewiring improves heme-suppressed efferocytosis and tissue damage in sickle cell disease.
巨噬细胞代谢重编程可改善镰状细胞病中血红素抑制的胞噬作用和组织损伤。
Blood. 2023 Jun 22;141(25):3091-3108. doi: 10.1182/blood.2022018026.
4
The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation.铁在慢性炎症性疾病中的作用：从机制到炎症性贫血的治疗选择。
Blood. 2022 Nov 10;140(19):2011-2023. doi: 10.1182/blood.2021013472.
5
20 years of Hepcidin: How far we have come.20 年的铁调素研究：我们走了多远。
Semin Hematol. 2021 Jul;58(3):132-144. doi: 10.1053/j.seminhematol.2021.05.001. Epub 2021 Jun 12.
6
Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.肝内肝素硫酸是人类肝细胞和小鼠中铁调素表达和铁稳态的主要调节物。
J Biol Chem. 2019 Sep 6;294(36):13292-13303. doi: 10.1074/jbc.RA118.007213. Epub 2019 Jul 17.
7
The role of heparin, heparanase and heparan sulfates in hepcidin regulation.肝素、乙酰肝素酶和硫酸乙酰肝素在铁调素调节中的作用。
Vitam Horm. 2019;110:157-188. doi: 10.1016/bs.vh.2019.01.008. Epub 2019 Feb 11.
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Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model.转铁蛋白受体 2 是治疗 β-地中海贫血的潜在新靶点：来自小鼠模型的证据。
Blood. 2018 Nov 22;132(21):2286-2297. doi: 10.1182/blood-2018-05-852277. Epub 2018 Sep 12.
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Blood. 2016 Jan 28;127(4):473-86. doi: 10.1182/blood-2015-08-663245. Epub 2015 Dec 16.