Luo Xiaozhen, Yang Lili, Chen Jing, Zhang Jing, Zhao Quanqing, Zhu Jiang
Department of Medical Oncology, Shangjin Nanfu Hospital, West China Hospital, Chengdu, China.
Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.
Front Psychiatry. 2023 Sep 20;14:1221262. doi: 10.3389/fpsyt.2023.1221262. eCollection 2023.
To investigate the impact of chemotherapy induced nausea and vomiting (CINV) on the anxiety and depression of the primary family caregivers of patients with cancer.
This study screened family caregivers of patients with cancer undergoing highly emetogenic chemotherapy (HEC) containing a 3-day cisplatin regime. Caregivers who did not experience anxiety or depression at baseline screening were enrolled in this study. Based on the patients' CINV status during chemotherapy, their family caregivers were divided into two groups: patients who experienced CINV (CINV group) and patients who did not experience CINV (No-CINV group). All enrolled family caregivers completed the Hospital Anxiety and Depression Scale (HADS) questionnaire on the fourth and 8 days of chemotherapy.
A total of 256 family caregivers were screened for this study, of which 195 caregivers without anxiety or depression at baseline were included. A total of 150 (76.9%) patients undergoing chemotherapy experienced acute CINV; 63 (42%) of their family caregivers experienced anxiety, and 65 (43.3%) developed depression. This was significantly higher than the experiences of the No-CINV group (2.2%, < 0.001; 0%, < 0.001, respectively). Among the patients undergoing chemotherapy, 86 (44.1%) experienced delayed CINV. The incidence of anxiety and depression in the family caregivers of patients with delayed CINV were 27.9 and 36%, respectively, both of which were significantly higher than that in the family caregivers of the No-CINV group (0.9%, < 0.001; and 0.9%, < 0.001, respectively).
Acute and delayed CINV occurring in patients during chemotherapy may induce anxiety and depression in their family caregivers.
探讨化疗所致恶心呕吐（CINV）对癌症患者主要家庭照顾者焦虑和抑郁的影响。
本研究筛选了正在接受含3天顺铂方案的高致吐性化疗（HEC）的癌症患者的家庭照顾者。在基线筛查时未出现焦虑或抑郁的照顾者被纳入本研究。根据化疗期间患者的CINV状态，将其家庭照顾者分为两组：经历CINV的患者（CINV组）和未经历CINV的患者（无CINV组）。所有纳入的家庭照顾者在化疗的第4天和第8天完成医院焦虑抑郁量表（HADS）问卷。
本研究共筛选了256名家庭照顾者，其中195名在基线时无焦虑或抑郁的照顾者被纳入。共有150名（76.9%）接受化疗的患者经历了急性CINV；其63名（42%）家庭照顾者出现焦虑，65名（43.3%）出现抑郁。这显著高于无CINV组（分别为2.2%，<0.001；0%，<0.001）。在接受化疗的患者中，86名（44.1%）经历了延迟性CINV。延迟性CINV患者家庭照顾者的焦虑和抑郁发生率分别为27.9%和36%，均显著高于无CINV组家庭照顾者（分别为0.9%，<0.001；0.9%，<0.001）。
化疗期间患者出现的急性和延迟性CINV可能会导致其家庭照顾者出现焦虑和抑郁。
