Harle D G, Baldo B A, Smal M A, Wajon P, Fisher M M
Clin Allergy. 1986 Sep;16(5):493-8. doi: 10.1111/j.1365-2222.1986.tb01984.x.
A radioimmunoassay was developed to detect IgE antibodies to the anaesthetic induction agent thiopentone. Significant levels of thiopentone-reactive IgE antibodies were found in the sera of two patients who had experienced life-threatening anaphylactoid reactions following administration of the drug. Inhibition experiments revealed that cross-reactivity occurs between the drug-reactive IgE antibodies and four barbiturate analogues pentobarbitone, phenobarbitone, barbitone and methohexital. The assay should supplement skin testing for the detection of patients with potentially lethal sensitivity to thiopentone.
已开发出一种放射免疫分析法来检测针对麻醉诱导剂硫喷妥钠的IgE抗体。在两名用药后发生危及生命的类过敏反应的患者血清中，发现了显著水平的硫喷妥钠反应性IgE抗体。抑制实验表明，药物反应性IgE抗体与四种巴比妥酸盐类似物戊巴比妥、苯巴比妥、巴比妥和甲己炔巴比妥之间存在交叉反应。该检测方法应作为皮肤试验的补充，用于检测对硫喷妥钠有潜在致命敏感性的患者。
