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利用铁蛋白标记抗体技术确定褐蛛毒液在人红细胞上的附着位点。

Location of brown recluse venom attachment sites on human erythrocytes by the firritin-labeled antibody technique.

作者信息

Futrell J M, Morgan P N, Su S P, Roth S I

出版信息

Am J Pathol. 1979 Jun;95(3):675-82.

PMID:377995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2042310/
Abstract

Brown recluse spider (loxosceles reclusa) venom has been demonstrated by a ferritin-labeled antibody technique to attach to human erythrocyte cell membranes. The number of individual attachment sites per cell is proportional to the concentration of the venom used to sensitize the erythrocytes. Structural changes in the red cell membrane are associated with the venom attachment. These sites may be related to the red cell hemolysis which sometimes occurs in the human as a result of the spider bite.

摘要

通过铁蛋白标记抗体技术已证实，棕色遁蛛（褐蛛）毒液可附着于人类红细胞细胞膜。每个细胞上单个附着位点的数量与用于使红细胞致敏的毒液浓度成正比。红细胞膜的结构变化与毒液附着有关。这些位点可能与人类有时因蜘蛛叮咬而发生的红细胞溶血有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07cf/2042310/03ef2c34328f/amjpathol00244-0106-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07cf/2042310/814b1f2c3cf4/amjpathol00244-0105-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07cf/2042310/0d053cd5685b/amjpathol00244-0105-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07cf/2042310/e231bbd0f8d9/amjpathol00244-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07cf/2042310/03ef2c34328f/amjpathol00244-0106-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07cf/2042310/814b1f2c3cf4/amjpathol00244-0105-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07cf/2042310/0d053cd5685b/amjpathol00244-0105-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07cf/2042310/e231bbd0f8d9/amjpathol00244-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07cf/2042310/03ef2c34328f/amjpathol00244-0106-b.jpg

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本文引用的文献

1
Hemolytic anemia from brown spider bite, necrotic arachnidism.
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2
The gangrenous bite of the Brown Recluse spider in Arkansas.阿肯色州棕色遁蛛造成的坏疽性咬伤。
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Improvements in epoxy resin embedding methods.环氧树脂包埋方法的改进。
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Hemolysis, renal failure and death, presumed secondary to bite of brown recluse spider.溶血、肾衰竭及死亡，推测为棕色隐士蜘蛛叮咬所致。
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Preliminary studies on venom from the brown recluse spider Loxosceles reclusa.关于褐皮隐居蛛毒液的初步研究。
Toxicon. 1969 Feb;6(3):161-5. doi: 10.1016/0041-0101(69)90115-9.
7
Variation in severity of loxoscelism.蜘蛛毒中毒严重程度的差异。
J Tenn Med Assoc. 1968 Nov;61(11):1097-103.
8
The role of polymorphonuclear leukocytes in the lesion caused by the venom of the brown spider, Loxosceles reclusa.
Lab Invest. 1970 Jan;22(1):90-3.
9
Lysis of human erythrocytes by venom from the brown recluse spider, Loxosceles reclusa.褐皮隐居蛛（Loxosceles reclusa）毒液对人类红细胞的溶解作用。
Toxicon. 1978;16(1):85-8. doi: 10.1016/0041-0101(78)90066-1.
10
Identification and neutralization of biological activities associated with venom from the brown recluse spider, Loxosceles reclusa.
Am J Trop Med Hyg. 1977 Nov;26(6 Pt 1):1206-11. doi: 10.4269/ajtmh.1977.26.1206.