Birla Siddharth, Angural Arshia, Madathumchalil Arya, Shende Ritika V, Shastry Sharvani V, Mahadevappa Manjappa, Shambhu Sunil Kumar, Vishwanath Prashant, Prashant Akila
Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysuru, Karnataka, India.
Department of Medical Genetics, JSS Medical College, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysuru, Karnataka, India.
Front Pharmacol. 2023 Sep 19;14:1268119. doi: 10.3389/fphar.2023.1268119. eCollection 2023.
Polypill is a multi-drug formulation in a single pill intended to simplify the drug regimen and reduce medication-induced adverse effects. The most common multidrug combinations in a polypill are used to treat cardiovascular diseases and are targeted against key modifiable risk factors such as hypertension and hyperlipidemia. These contain blood-pressure lowering agents, statins, and anti-platelet agents usually in a fixed dose. Polypills can be an affordable therapeutic intervention for treating high-risk patients, as these are proven to increase patients' adherence to medication and improve clinical outcomes. Over the previous years, randomized clinical trials of several polypills have yielded contradictory findings, raising skepticism regarding their widespread use in primary disease prevention. Here, we have reviewed the concept of polypills, the evidence-based strengths, the limitations of this polypharmacy intervention strategy, and discussed future directions for their use in the primary and secondary preventive management of cardiovascular diseases and associated risk factors.
多效药丸是一种将多种药物组合在一粒药丸中的制剂，旨在简化药物治疗方案并减少药物引起的不良反应。多效药丸中最常见的多种药物组合用于治疗心血管疾病，针对的是高血压和高脂血症等关键的可改变风险因素。这些药物通常包含固定剂量的降压药、他汀类药物和抗血小板药物。多效药丸对于治疗高危患者而言可能是一种经济实惠的治疗干预措施，因为事实证明这些药丸可提高患者的用药依从性并改善临床结局。在过去几年中，几种多效药丸的随机临床试验得出了相互矛盾的结果，这引发了人们对其在原发性疾病预防中广泛应用的质疑。在此，我们回顾了多效药丸的概念、基于证据的优势、这种多药联合干预策略的局限性，并讨论了其在心血管疾病及相关风险因素的一级和二级预防管理中的未来应用方向。
