Nehra Nidhi, Kaushik Rahul
School of Chemical Sciences, Indian Association for the Cultivation of Science, Kolkata 700032, India.
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India.
Anal Methods. 2023 Oct 19;15(40):5268-5285. doi: 10.1039/d3ay01249b.
Fluorescent and colourimetric probes for small analytes (cations, anions and neutral molecules) have drawn significant attention in recent years. These probes interact with analytes and induce spectral change due to the variations in the photo-physical properties of the fluorophore/chromophore used. Among several photo-physical mechanisms, ESIPT (excited state intramolecular proton transfer) based probes are more advantageous due to their photo-physical properties solvent polarity effect, large spectral shift with multi-channel fluorescence, high quantum yield In recent years, ESIPT-based probes have shown several promising applications, especially monitoring small analytes in biological samples, smartphone app-assisted heavy metal detection in environmental samples, inkless writing, anti-counterfeiting applications Therefore, this review is dedicated to recently reported ESIPT-based probes for small analytes. We have highlighted the organic units responsible for the ESIPT mechanism, their photo-physical parameters, selectivity and sensitivity properties and recent advances in their applications.
近年来，用于检测小分子分析物（阳离子、阴离子和中性分子）的荧光和比色探针受到了广泛关注。这些探针与分析物相互作用，并由于所使用的荧光团/发色团光物理性质的变化而引起光谱变化。在几种光物理机制中，基于激发态分子内质子转移（ESIPT）的探针因其光物理性质、溶剂极性效应、多通道荧光的大光谱位移、高量子产率而更具优势。近年来，基于ESIPT的探针已显示出多种有前景的应用，特别是监测生物样品中的小分子分析物、环境样品中智能手机应用辅助的重金属检测、无墨书写、防伪应用。因此，本综述致力于介绍最近报道的用于小分子分析物的基于ESIPT的探针。我们重点介绍了负责ESIPT机制的有机单元、它们的光物理参数、选择性和灵敏度特性以及它们在应用方面的最新进展。
