Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Department of Neurology, 980th Hospital of PLA Joint Logistical Support Force (Bethune International Peace Hospital), Shijiazhuang, China.
Medicine (Baltimore). 2023 Oct 6;102(40):e35389. doi: 10.1097/MD.0000000000035389.
Cerebral small vessel disease (CSVD) is a chronic global brain disease mainly involving small blood vessels in the brain. The disease can be gradually aggravated with the increase of age, so it is the primary cause of brain dysfunction in the elderly. With the increasing aging of the world population and the high incidence of cerebrovascular risk factors, the incidence of CSVD is increasing day by day. CSVD is characterized by insidious onset, slow progression, diverse clinical manifestations, and difficult early diagnosis. CSVD can lead to cognitive impairment, gait impairment, affective impairment, and so on. however, it has not received enough attention from researchers in the past. In recent years, some studies have shown that CSVD patients have a high proportion of related impairment, which seriously affect patients daily life and social functions. Currently, no clear preventive measures or treatments exist to improve the condition. With the development of magnetic resonance imaging, CSVD has become more and more recognized and the detection rate has gradually improved. This paper reviews the research progress of magnetic resonance imaging and cognitive impairment, gait impairment, affective impairment, urination disorder, swallowing disorder, and other disorders to provide a useful reference for the early diagnosis and treatment of CSVD and expand new ideas.
脑小血管病(CSVD)是一种主要累及脑内小血管的慢性全脑疾病。随着年龄的增长,疾病逐渐加重,是老年人脑功能障碍的主要原因。随着世界人口老龄化的加剧和脑血管危险因素的高发,CSVD 的发病率日益增高。CSVD 起病隐匿,进展缓慢,临床表现多样,早期诊断困难。CSVD 可导致认知障碍、步态障碍、情感障碍等,但过去并未得到研究者的足够重视。近年来,一些研究表明 CSVD 患者存在较高比例的相关损害,严重影响患者日常生活和社会功能。目前,尚无明确的预防措施或治疗方法来改善病情。随着磁共振成像的发展,CSVD 越来越受到重视,检出率逐渐提高。本文就磁共振成像在 CSVD 认知障碍、步态障碍、情感障碍、排尿障碍、吞咽障碍等方面的研究进展进行综述,为 CSVD 的早期诊断和治疗提供有益参考,拓展新的思路。