Phenomic and transcriptomic analyses reveal the sequential synthesis of FeO nanoparticles in BYM.

As the most important non-magnetotactic magnetosome-producing bacteria, only requires very mild conditions to produce FeO nanoparticles, thus conferring greater flexibility and potential application in biomagnetic nanoparticle production. However, the available information cannot explain the mechanism of FeO nanoparticle formation in . In this study, we applied phenomic and transcriptomic analyses to reveal this mechanism. We found that different treatment condition factors notably affect the phenomic data of FeO nanoparticle in . Using transcriptomic analyses, the gene network controlling/regulating FeO nanoparticle biogenesis in was proposed, excavating the candidate hub genes for FeO nanoparticle formation in . Based on this information, a sequential model for FeO nanoparticle synthesis in was hypothesized. It lays the groundwork for further clarifying the feature of FeO nanoparticle synthesis.