College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, China.
Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, Zhejiang University of Technology, Hangzhou, 310014, China.
J Agric Food Chem. 2023 Oct 18;71(41):14870-14889. doi: 10.1021/acs.jafc.3c04154. Epub 2023 Oct 6.
, a plant in the Orchidaceae family, has been used in traditional Chinese medicine for thousands of years. Sweet and slightly cold in nature, it can invigorate the stomach, promote fluid production, nourish Yin, and dissipate heat. Over the past decade, more than 60 compounds have been derived from , including flavonoids, bibenzyl, and phenanthrene. Various studies have explored the underlying pharmacological mechanisms of these compounds, which have shown antitumor, hypoglycemic, hypertensive, gastrointestinal-regulatory, visceral organ protection, antiaging, and neurorestorative effects. This paper presents a systematic review of the structural classification, biological activity, and pharmacological mechanisms of different chemical components obtained from over the past decade. This review aims to provide a reference for future study and establish a foundation for clinical applications. Furthermore, this review identifies potential shortcomings in current research as well as potential directions and methodologies in future plant research.
铁皮石斛，兰科植物，在中国传统医学中应用已有数千年。其性甘寒，能养胃生津、滋阴除热。在过去的十年中，已从铁皮石斛中分离得到 60 多种化合物，包括类黄酮、联苄类和菲类化合物。各种研究探索了这些化合物的潜在药理机制，表明其具有抗肿瘤、降血糖、降血压、调节胃肠、保护内脏器官、抗衰老和神经修复作用。本文对过去十年从铁皮石斛中获得的不同化学成分的结构分类、生物活性和药理机制进行了系统综述。本文旨在为今后的研究提供参考，为临床应用奠定基础。此外，本文还指出了当前研究中的潜在不足以及未来植物研究的潜在方向和方法。
