Guo Hong, Zhou Bei, Chang Jingjing, Chang Wenxu, Feng Jiyao, Zhang Zhenhua
College of Science, China Agricultural University, Beijing 100193, China.
Org Biomol Chem. 2023 Oct 18;21(40):8054-8074. doi: 10.1039/d3ob01115a.
Heterocyclic compounds, both naturally derived and synthetically produced, constitute a wide variety of biologically active and industrially important compounds. The synthesis and application of heterocyclic compounds have garnered significant attention and experienced rapid growth in recent decades. Organic azides, due to their unique properties and distinctive reactivity, have become a convenient chemical tool for achieving a wide range of heterocycles such as triazoles and tetrazoles. Importantly, the field of multicomponent reaction (MCR) chemistry provides a convergent approach to access various N-heterocyclic scaffolds, offering novelty, diversity, and complexity. However, the exploration of MCR pathways to N-heterocyclic compounds remains incomplete. Here, we review the use of multicomponent reactions for the preparation of N-heterocycles. A wide range of reactions based on azides for the synthesis of various types of N-heterocyclic systems have been developed.
杂环化合物，无论是天然衍生的还是人工合成的，都构成了各种各样具有生物活性和工业重要性的化合物。近几十年来，杂环化合物的合成与应用受到了广泛关注并取得了迅速发展。有机叠氮化物因其独特的性质和显著的反应活性，已成为实现多种杂环化合物（如三唑和四唑）的便捷化学工具。重要的是，多组分反应（MCR）化学领域提供了一种汇聚式方法来构建各种含氮杂环骨架，具有新颖性、多样性和复杂性。然而，通往含氮杂环化合物的MCR途径的探索仍不完整。在此，我们综述了多组分反应在制备含氮杂环化合物中的应用。基于叠氮化物已开发出了一系列用于合成各种类型含氮杂环体系的反应。
