Department of Chemistry, Maitreyi College, University of Delhi, Bapu Dham Complex, Chanakyapuri, 110007, India.
Mol Divers. 2021 May;25(2):1211-1245. doi: 10.1007/s11030-020-10076-4. Epub 2020 Mar 23.
2-Naphthol or β-naphthol is an important starting material that has drawn great attention in various organic transformations because of its attributes, such as low cost, easy to handle and eco-friendliness. The electron-rich aromatic framework of 2-naphthol with multiple reactive sites allows it to be utilized in several kinds of organic reactions eventuated to several organic molecules with potent biological properties. Multicomponent reaction approach has been tremendously utilized to explore the synthetic utility of 2-naphthol for the construction of diverse N/O-containing heterocyclic framework. In this review, we summarize recent data pertaining to multicomponent reactions, wherein heterocyclic compounds are synthesized utilizing 2-naphthol as one of the starting materials. It is anticipated that this review will stimulate the researchers to design new multicomponent strategies complying with the Green Chemistry principles for the further exploitation of 2-naphthol for the rapid synthesis of versatile biologically relevant heterocycles. This review provides a concise overview of the different 2-naphthol based multicomponent reactions utilized for the construction of diverse bioactive heterocyclic scaffold.
2-萘酚或β-萘酚是一种重要的起始原料，由于其成本低、易于处理和环保等特性，在各种有机转化中引起了极大的关注。2-萘酚具有富电子的芳香骨架和多个反应位点，可用于多种有机反应，生成具有潜在生物活性的多种有机分子。多组分反应方法已被广泛用于探索 2-萘酚在构建各种含 N/O 的杂环骨架方面的合成应用。本文综述了近年来利用 2-萘酚作为起始原料之一合成杂环化合物的多组分反应的最新数据。预计这篇综述将激发研究人员设计新的符合绿色化学原则的多组分策略，进一步开发 2-萘酚，以快速合成多功能的具有生物学意义的杂环。本文综述了不同的基于 2-萘酚的多组分反应在构建各种生物活性杂环骨架方面的应用。
