Goto I, Kawano Y, Tsuchiya T, Tamagawa Y, Kuroiwa Y
Clin Neurol Neurosurg. 1986;88(3):193-6. doi: 10.1016/s0303-8467(86)80028-2.
Plasma copper was significantly reduced in Wilson's disease with decreased ceruloplasmin levels, while there was no significant difference in erythrocyte copper levels between Wilson's disease and controls. Mean zinc and manganese levels in plasma were increased in Wilson's disease, but these differences were not significant. Mean magnesium level in plasma was normal. The levels of these metals in erythrocytes showed no difference between Wilson's disease and controls. Our results suggest that the abnormal copper level in plasma is not due to the primary metabolic defects, but is probanly due to the level of the binding proteins in plasma to this metal, ceruloplasmin, in Wilson's disease.
在威尔逊病中，随着血浆铜蓝蛋白水平降低，血浆铜显著减少，而威尔逊病患者与对照组之间红细胞铜水平无显著差异。威尔逊病患者血浆锌和锰的平均水平升高，但这些差异不显著。血浆镁平均水平正常。威尔逊病患者与对照组之间红细胞中这些金属的水平无差异。我们的结果表明，血浆中铜水平异常并非由于原发性代谢缺陷，而可能是由于威尔逊病中血浆中该金属结合蛋白——血浆铜蓝蛋白的水平所致。
