Hawash Ahmed, Nguyen Thu, Mantilla Ana, Emesiani Christine, Meckfessel Matthew
J Drugs Dermatol. 2023 Oct 1;22(10):SF388641s10-SF388641s15. doi: 10.36849/JDD.8641.
Study to compare efficacy, tolerability, and patient perception between an over-the-counter itch relief gel (IRG) and itch relief moisturizing cream (IRMC) after a single application. Methods: Single-center, randomized, blinded, split-body study comparing IRG vs IRMC in adults with eczema-prone skin and mild-to-moderate itch. Assessments included itch relief duration upon application, itch severity (0=none to 9=severe at baseline [BL], 8, 12, and 24 hours), tolerability (0=none to 3=severe), and self-assessment questionnaire about product attributes and preference. Results: Thirty-three females and males with a mean age of 49.7 completed the study. Average time to itch relief was 28.5 seconds for IRG vs 41.8 for IRMC (P<0.05), with first onset at 5 seconds. In the IRG group, itch severity was reduced from 4.4 at BL to 1.4 at 8 hours; in comparison, itch was reduced from 4.4 at BL to 2.6 at 8 hours in the IRMC group (P<0.05). Both products significantly relieved itch vs baseline at all time points. IRG had better tolerability, with burning/stinging going from 1.5 at BL to 0.8 at 24 hours vs 1.5 at BL to 1.2 at 24 hours for IRMC (P<0.05). There was a trend in favor of IRG vs IRMC on the patient satisfaction self-assessment questionnaire.
IRG provided rapid itch relief and significantly outperformed IRMC. Both products significantly improved itch severity for up to 24 hours after application, with IRG outperforming IRMC at 8 hours. Additionally, IRG moderated stinging/burning sensations better than IRMC. Further, IRG was preferred by participants over IRMC.J Drugs Dermatol. 2023;22:10(Suppl 2):s10-15.  .
进行一项研究，比较非处方止痒凝胶（IRG）和止痒保湿霜（IRMC）单次应用后的疗效、耐受性和患者感受。方法：单中心、随机、双盲、自身对照研究，比较IRG和IRMC对易患湿疹皮肤且有轻至中度瘙痒的成年人的效果。评估内容包括应用后止痒持续时间、瘙痒严重程度（0=无至9=基线时[BL]严重，8、12和24小时）、耐受性（0=无至3=严重）以及关于产品特性和偏好的自我评估问卷。结果：33名平均年龄为49.7岁的男性和女性完成了研究。IRG的平均止痒时间为28.5秒，而IRMC为41.8秒（P<0.05），首次起效时间为5秒。在IRG组中，瘙痒严重程度从基线时的4.4降至8小时时的1.4；相比之下，IRMC组的瘙痒从基线时的4.4降至8小时时的2.6（P<0.05）。两种产品在所有时间点均比基线时显著减轻瘙痒。IRG的耐受性更好，灼痛/刺痛从基线时的1.5降至24小时时的0.8，而IRMC从基线时的1.5降至24小时时的1.2（P<0.05）。在患者满意度自我评估问卷中，有倾向于IRG优于IRMC的趋势。结论：IRG能迅速缓解瘙痒，且明显优于IRMC。两种产品在应用后长达24小时内均显著改善瘙痒严重程度，在8小时时IRG优于IRMC。此外，IRG比IRMC更能减轻刺痛/灼痛感觉。此外，与IRMC相比，参与者更偏好IRG。《药物皮肤病学杂志》。2023；22：10（增刊2）：s10 - 15。
