Weber Teresa M, Babcock Michael J, Herndon James H, Schoelermann Andrea M, Filbry Alexander W, Scherdin Ulrich, Neufang Gitta, Rippke Frank
J Drugs Dermatol. 2014 May;13(5):589-95.
Two over-the-counter products have been clinically tested for efficacy and tolerability in the treatment of atopic dermatitis. Study 1 evaluated a daily maintenance Body Cream (Eucerin Eczema Relief Body Crème) applied twice daily for 14 days, followed by treatment withdrawal for 5 days (regression period) in subjects with a history of atopic dermatitis. Study 2 evaluated an acute treatment (Eucerin Eczema Relief Instant Therapy [Instant Therapy]) for active atopic dermatitis lesions administered for 14 days. Skin barrier function, hydration, tolerability, and relief of symptoms were assessed at baseline, day 7, and day 14. Study 2 also measured itch relief and treatment impact on work, social activities, and sleep. Body Cream significantly improved skin hydration and barrier function (P<.001) at 14 days, with improvements persisting through the 5-day regression phase. Itching was significantly improved in 93.8% of subjects (P<.001). Instant Therapy treatment of atopic dermatitis lesions significantly improved skin hydration and barrier function, as well as symptoms of erythema, pruritus, excoriation, and lichenification, with rapid improvement of itch reported within minutes of the first treatment application. Instant Therapy significantly reduced itch intensity and frequency, and demonstrated beneficial improvements in subjects' quality of life. Body Cream and Instant Therapy were both safe and well tolerated.
两种非处方产品已针对特应性皮炎的治疗进行了疗效和耐受性的临床测试。研究1评估了一种每日使用的身体乳霜（优色林舒缓湿疹身体乳），对有特应性皮炎病史的受试者，每天涂抹两次，持续14天，然后停药5天（回归期）。研究2评估了一种用于治疗活动性特应性皮炎皮损的急性治疗产品（优色林舒缓湿疹即时疗法[即时疗法]），使用14天。在基线、第7天和第14天评估皮肤屏障功能、水合作用、耐受性和症状缓解情况。研究2还测量了瘙痒缓解情况以及治疗对工作、社交活动和睡眠的影响。身体乳霜在14天时显著改善了皮肤水合作用和屏障功能（P<0.001），且这些改善在5天的回归期内持续存在。93.8%的受试者瘙痒症状显著改善（P<0.001）。即时疗法治疗特应性皮炎皮损显著改善了皮肤水合作用和屏障功能，以及红斑、瘙痒、擦伤和苔藓化症状，在首次使用治疗后几分钟内瘙痒就迅速改善。即时疗法显著降低了瘙痒强度和频率，并在受试者的生活质量方面显示出有益的改善。身体乳霜和即时疗法均安全且耐受性良好。
