酰基乙炔基苯并碘杂环戊二酮（酰基-EBX）：通向乙烯酮二硫代芳基缩醛的途径。
Acyl-Ethynylbenziodoxolone (acyl-EBX): Access to Ketene Dithioarylacetals.
作者信息
Palamini Pierre, Borrel Julien, Djaïd Maël, Delattre Morgane, Waser Jerome
机构信息
Laboratory of Catalysis and Organic Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland.
出版信息
Org Lett. 2023 Oct 20;25(41):7535-7539. doi: 10.1021/acs.orglett.3c02869. Epub 2023 Oct 6.
We report the synthesis of ketene dithioarylacetals in 40-97% yield using thiophenols and acyl-EBXs (ethynylbenziodoxolones) generated from a common hypervalent iodine precursor and alkynyl trifluoroborate salts. The products could be further modified to afford functionalized ketene dithioacetals and various -substituted heterocycles.
我们报道了使用苯硫酚和由常见的高价碘前体与炔基三氟硼酸盐生成的酰基-EBXs（乙炔基苯并碘恶唑酮），以40 - 97%的产率合成乙烯酮二硫代芳基缩醛。产物可进一步修饰以得到功能化的乙烯酮二硫代缩醛和各种β-取代的杂环化合物。
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