铜（I）催化的α-酰基-α-炔基酮二硫缩醛的杂环化反应：3-氰基呋喃的合成。
Copper(I)-Catalyzed Heterocyclization of α-Acyl-α-alkynyl Ketene Dithioacetals: Synthesis of 3-Cyanofurans.
机构信息
Department of Chemistry, Northeast Normal University , Changchun 130024, P. R. China.
出版信息
Org Lett. 2016 May 6;18(9):2162-5. doi: 10.1021/acs.orglett.6b00785. Epub 2016 Apr 13.
PMID:27074446
Abstract
A new method for the synthesis of 3-cyanofurans via Cu(I)-catalyzed heterocyclization of α-acyl-α-alkynyl ketene dithioacetals in the presence of ammonium acetate has been developed. The procedure generates the cyano moiety in situ with ammonium acetate as the nitrogen source. Based upon experimental observations, a plausible reaction mechanism is proposed.
摘要
一种新的方法，通过铜（I）催化的杂环化α-酰基-α-炔基硫缩酮二硫缩醛在醋酸铵的存在下合成 3-氰基呋喃。该过程中，以醋酸铵作为氮源原位生成氰基。基于实验观察，提出了一个合理的反应机制。
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