微血管密度（分化群 34 和血管内皮生长因子）在鼻咽血管纤维瘤中的临床相关性。
Microvessel density (Cluster of Differentiation-34 & Vascular Endothelial growth factor) in Nasopharyngeal Angiofibroma: Clinical correlation.
机构信息
Departments of Pathology, King George Medical University, Lucknow, India.
Otorhinolaryngology and Head and Neck Surgery, King George Medical University, Lucknow, India.
出版信息
Int J Pediatr Otorhinolaryngol. 2023 Nov;174:111746. doi: 10.1016/j.ijporl.2023.111746. Epub 2023 Sep 29.
BACKGROUND
The literature on microvessel density (MVD) signifying neoangiogenesis/tumour-activity in juvenile nasopharyngeal angiofibroma (JNA) is limited. Accordingly, this study evaluates and correlates MVD characteristics with clinical parameters/aggressiveness/recurrence.
MATERIAL AND METHODS
Sixty-two paraffin blocks of JNA were studied histopathologically and MVD was assessed following immunohistochemistry using VEGF and CD34 as vascular markers. A clinical correlation of MVD was undertaken in 43 cases.
RESULTS
MVD scores of VEGF and CD34 showed strong inter-correlation. The 'age', 'duration of disease' and 'haemoglobin%' were the only clinical parameters that revealed significance with MVD. Significantly higher MVD scores were appreciated in recurrent cases as well as some other clinical differences from upfront cases.
CONCLUSION
This is the first study of MVD with CD34 and VEGF simultaneously depicting clinical correlation. The strong correlation, supports a prognostic role of MVD scores in JNA and this can be better established in a larger multicentre study involving comprehensive examination of tumour dimensions.
背景
关于微血管密度（MVD）作为青少年鼻咽血管纤维瘤（JNA）新生血管形成/肿瘤活性的标志物的文献有限。因此，本研究评估并关联了 MVD 特征与临床参数/侵袭性/复发的关系。
材料与方法
对 62 例 JNA 的石蜡块进行组织病理学研究，并使用 VEGF 和 CD34 作为血管标志物进行免疫组织化学评估 MVD。对 43 例病例进行了 MVD 的临床相关性研究。
结果
VEGF 和 CD34 的 MVD 评分显示出强烈的相关性。“年龄”、“疾病持续时间”和“血红蛋白%”是与 MVD 有显著意义的唯一临床参数。复发病例的 MVD 评分明显较高，与初诊病例相比还有一些其他的临床差异。
结论
这是首次同时使用 CD34 和 VEGF 评估 MVD 并与临床相关性进行的研究。这种强烈的相关性支持 MVD 评分在 JNA 中的预后作用，这可以在一个更大的多中心研究中通过对肿瘤尺寸的全面检查来更好地建立。
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