CD34免疫阳性微血管密度在青少年鼻咽血管纤维瘤中的作用
Role of CD34-immunopositive Microvascular Density in Juvenile Nasopharyngeal Angiofibroma.
作者信息
Jaiswal Avinash Shekhar, Kumar Rakesh, Kakkar Aanchal, Kumar Rajeev, Verma Hitesh, Bhalla Ashu Seith, Kairo Arvind Kumar, Thakar Alok
机构信息
Department of Otorhinolaryngology and Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
出版信息
Indian J Otolaryngol Head Neck Surg. 2024 Apr;76(2):1503-1508. doi: 10.1007/s12070-023-04331-x. Epub 2023 Dec 20.
OBJECTIVE
To assess the microvascular density (MVD) in juvenile nasopharyngeal angiofibroma (JNA) with CD34 immunostaining and evaluate its relationship with clinico-demographic features.
METHODS
This prospective study included patients with JNA undergoing endoscopic excision. The histopathological specimen was stained using CD-34 antibodies to calculate MVD. MVD and clinico-demographic features were correlated.
RESULTS
The study included 12 patients with a median age of 15.5 years. The mean MVD was 39 vessels/high power field (range 5 to 151 vessels). MVD was significantly associated only with the volume of tumour (r = 0.65, p = 0.02). The recurrence occurred in one patient with an MVD of 107. The median follow-up was 38 months.
CONCLUSION
MVD is significantly associated with tumour volume in JNA, which implies a robust role of angiogenesis in the pathology of the tumour. Also, higher MVD may be a risk factor for recurrence.
目的
采用CD34免疫染色评估青少年鼻咽血管纤维瘤（JNA）中的微血管密度（MVD），并评估其与临床人口统计学特征的关系。
方法
这项前瞻性研究纳入了接受内镜切除的JNA患者。使用CD - 34抗体对组织病理学标本进行染色以计算MVD。对MVD与临床人口统计学特征进行相关性分析。
结果
该研究纳入了12例患者，中位年龄为15.5岁。平均MVD为39个血管/高倍视野（范围为5至151个血管）。MVD仅与肿瘤体积显著相关（r = 0.65，p = 0.02）。1例MVD为107的患者出现复发。中位随访时间为38个月。
结论
MVD与JNA中的肿瘤体积显著相关，这意味着血管生成在肿瘤病理过程中起重要作用。此外，较高的MVD可能是复发的危险因素。
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