Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, P. R. China.
School of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing, 101400, P. R. China.
Small. 2024 Feb;20(7):e2307087. doi: 10.1002/smll.202307087. Epub 2023 Oct 6.
The free radical generation efficiency of nanozymes in cancer therapy is crucial, but current methods fall short. Alloy nanoparticles (ANs) hold promise for improving catalytic performance due to their inherent electronic effect, but there are limited ways to modulate this effect. Here, a self-driven electric field (E) system utilizing triboelectric nanogenerator (TENG) and AuPd ANs with glucose oxidase (GOx)-like, catalase (CAT)-like, and peroxidase (POD)-like activities is presented to enhance the treatment of 4T1 breast cancer in mice. The E stimulation from TENG enhances the orbital electrons of AuPd ANs, resulting in increased CAT-like, GOx-like, and POD-like activities. Meanwhile, the catalytic cascade reaction of AuPd ANs is further amplified after catalyzing the production of H O from the GOx-like activities. This leads to 89.5% tumor inhibition after treatment. The self-driven E strategy offers a new way to enhance electronic effects and improve cascade catalytic therapeutic performance of AuPd ANs in cancer therapy.
纳米酶在癌症治疗中的自由基生成效率至关重要，但目前的方法还存在不足。合金纳米粒子（ANs）由于其固有的电子效应，有望提高催化性能，但调节这种效应的方法有限。在这里，提出了一种利用摩擦纳米发电机（TENG）和具有葡萄糖氧化酶（GOx）样、过氧化氢酶（CAT）样和过氧化物酶（POD）样活性的 AuPd ANs 的自驱动电场（E）系统，以增强对小鼠 4T1 乳腺癌的治疗效果。TENG 产生的 E 刺激增强了 AuPd ANs 的轨道电子，从而提高了 CAT 样、GOx 样和 POD 样活性。同时，AuPd ANs 在催化 GOx 样活性产生 H O 后，进一步放大了催化级联反应。治疗后肿瘤抑制率达到 89.5%。自驱动 E 策略为增强电子效应和提高 AuPd ANs 在癌症治疗中的级联催化治疗性能提供了一种新方法。
