Frackowiak Bruno, Van den Bosch Vincent, Tokoutsi Zoi, Baragona Marco, de Greef Martijn, Elevelt Aaldert, Isfort Peter
Philips Research, Data Science & Digital Twin, 5656 AE, Eindhoven, The Netherlands.
Department of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, 52074, Aachen, Germany.
Sci Rep. 2023 Oct 6;13(1):16862. doi: 10.1038/s41598-023-42543-x.
A model-based planning tool, integrated in an imaging system, is envisioned for CT-guided percutaneous microwave ablation. This study aims to evaluate the biophysical model performance, by comparing its prediction retrospectively with the actual ablation ground truth from a clinical dataset in liver. The biophysical model uses a simplified formulation of heat deposition on the applicator and a heat sink related to vasculature to solve the bioheat equation. A performance metric is defined to assess how the planned ablation overlaps the actual ground truth. Results demonstrate superiority of this model prediction compared to manufacturer tabulated data and a significant influence of the vasculature cooling effect. Nevertheless, vasculature shortage due to branches occlusion and applicator misalignment due to registration error between scans affects the thermal prediction. With a more accurate vasculature segmentation, occlusion risk can be estimated, whereas branches can be used as liver landmarks to improve the registration accuracy. Overall, this study emphasizes the benefit of a model-based thermal ablation solution in better planning the ablation procedures. Contrast and registration protocols must be adapted to facilitate its integration into the clinical workflow.
设想在成像系统中集成一种基于模型的规划工具，用于CT引导下的经皮微波消融。本研究旨在通过将其预测结果与来自肝脏临床数据集的实际消融真实情况进行回顾性比较，评估生物物理模型的性能。该生物物理模型使用了一种简化的施药器热沉积公式以及与脉管系统相关的热沉来求解生物热方程。定义了一个性能指标来评估计划消融与实际真实情况的重叠程度。结果表明，与制造商的列表数据相比，该模型预测具有优越性，并且脉管系统冷却效应有显著影响。然而，由于分支闭塞导致的脉管系统短缺以及扫描之间配准误差导致的施药器错位会影响热预测。通过更准确的脉管系统分割，可以估计闭塞风险，而分支可作为肝脏标志物来提高配准精度。总体而言，本研究强调了基于模型的热消融解决方案在更好地规划消融程序方面的益处。必须调整造影和配准方案，以促进其融入临床工作流程。
