G蛋白偶联受体（GPCRs）细胞内偏向性激动剂的结构见解 - Suppr

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Structural insights into an intracellular biased agonist for GPCRs.

作者信息

Soni Neeraj, Das Tarumoy, Baidya Mithu

机构信息

Department of Biosciences and Bioengineering, Indian Institute of Technology Jammu, Jammu, India.

出版信息

Nat Struct Mol Biol. 2023 Nov;30(11):1612-1614. doi: 10.1038/s41594-023-01100-w.

DOI:10.1038/s41594-023-01100-w

PMID:37803065

Abstract

摘要

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Molecular mechanism of fatty acid activation of FFAR1.

Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2219569120. doi: 10.1073/pnas.2219569120. Epub 2023 May 22.

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Nat Rev Drug Discov. 2023 May;22(5):347-348. doi: 10.1038/d41573-023-00064-2.

Structural basis of efficacy-driven ligand selectivity at GPCRs.

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New Binding Sites, New Opportunities for GPCR Drug Discovery.

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Intracellular Receptor Modulation: Novel Approach to Target GPCRs.

Trends Pharmacol Sci. 2018 Jun;39(6):547-559. doi: 10.1016/j.tips.2018.03.002. Epub 2018 Apr 10.

Biased signalling: from simple switches to allosteric microprocessors.

Nat Rev Drug Discov. 2018 Apr;17(4):243-260. doi: 10.1038/nrd.2017.229. Epub 2018 Jan 5.

Trends in GPCR drug discovery: new agents, targets and indications.

Nat Rev Drug Discov. 2017 Dec;16(12):829-842. doi: 10.1038/nrd.2017.178. Epub 2017 Oct 27.

Frozen in action: cryo-EM structure of a GPCR-G-protein complex.

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Structural insights into an intracellular biased agonist for GPCRs.

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Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6733-8. doi: 10.1073/pnas.1201093109. Epub 2012 Apr 9.

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Pharmacol Ther. 2019 Aug;200:148-178. doi: 10.1016/j.pharmthera.2019.05.006. Epub 2019 May 8.

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Trends Biochem Sci. 2014 Dec;39(12):594-602. doi: 10.1016/j.tibs.2014.10.001. Epub 2014 Nov 4.

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Nat Chem Biol. 2018 Feb;14(2):126-134. doi: 10.1038/nchembio.2527. Epub 2017 Dec 11.

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FEBS J. 2014 Oct;281(20):4659-71. doi: 10.1111/febs.12970. Epub 2014 Sep 17.

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引用本文的文献

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本文引用的文献

Class B1 GPCR activation by an intracellular agonist.

Nature. 2023 Jun;618(7967):1085-1093. doi: 10.1038/s41586-023-06169-3. Epub 2023 Jun 7.

Molecular mechanism of fatty acid activation of FFAR1.

Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2219569120. doi: 10.1073/pnas.2219569120. Epub 2023 May 22.

Setting GPCRs free.

Nat Rev Drug Discov. 2023 May;22(5):347-348. doi: 10.1038/d41573-023-00064-2.

Structural basis of efficacy-driven ligand selectivity at GPCRs.

Nat Chem Biol. 2023 Jul;19(7):805-814. doi: 10.1038/s41589-022-01247-5. Epub 2023 Feb 13.

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Trends Biochem Sci. 2019 Apr;44(4):312-330. doi: 10.1016/j.tibs.2018.11.011. Epub 2019 Jan 3.

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Nat Rev Drug Discov. 2018 Apr;17(4):243-260. doi: 10.1038/nrd.2017.229. Epub 2018 Jan 5.

Trends in GPCR drug discovery: new agents, targets and indications.

Nat Rev Drug Discov. 2017 Dec;16(12):829-842. doi: 10.1038/nrd.2017.178. Epub 2017 Oct 27.

Frozen in action: cryo-EM structure of a GPCR-G-protein complex.

Nat Struct Mol Biol. 2017 Jun 6;24(6):500-502. doi: 10.1038/nsmb.3418.

Diversity and modularity of G protein-coupled receptor structures.

Trends Pharmacol Sci. 2012 Jan;33(1):17-27. doi: 10.1016/j.tips.2011.09.003. Epub 2011 Oct 25.