The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
College of Pharmaceutical Sciences, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
Small. 2024 Feb;20(7):e2305426. doi: 10.1002/smll.202305426. Epub 2023 Oct 6.
Photothermal therapy (PTT), which employs nanoscale transducers delivered into a tumor to locally generate heat upon irradiation with near-infrared light, shows great potential in killing cancer cells through hyperthermia. The efficacy of such a treatment is determined by a number of factors, including the amount, distribution, and dissipation of the generated heat, as well as the type of cancer cell involved. The amount of heat generated is largely controlled by the number of transducers accumulated inside the tumor, the absorption coefficient and photothermal conversion efficiency of the transducer, and the irradiance of the light. The efficacy of treatment depends on the distribution of the transducers in the tumor and the penetration depth of the light. The vascularity and tissue thermal conduction both affect the dissipation of heat and thereby the distribution of temperature. The successful implementation of PTT in the clinic setting critically depends on techniques for real-time monitoring and management of temperature.
光热疗法（PTT）利用纳米级换能器递送至肿瘤中，在近红外光照射下局部产生热量，通过高热来杀死癌细胞。这种治疗的效果取决于多种因素，包括产生的热量的数量、分布和耗散，以及所涉及的癌细胞类型。产生的热量的数量主要由肿瘤内积累的换能器的数量、换能器的吸收系数和光热转换效率以及光的辐照度来控制。治疗的效果取决于换能器在肿瘤中的分布和光的穿透深度。血管生成和组织热传导都会影响热量的耗散，从而影响温度的分布。PTT 在临床环境中的成功实施严重依赖于实时监测和温度管理技术。
