Xu Jiaqi, Song Mengdi, Fang Zhou, Zheng Lanxi, Huang Xiaoya, Liu Kehai
Department of Biopharmaceutical Science, Shanghai Ocean University, Hucheng Ring Road, Shanghai 201306, China.
Department of Biopharmaceutical Science, Shanghai Ocean University, Hucheng Ring Road, Shanghai 201306, China.
J Control Release. 2023 Jan;353:699-712. doi: 10.1016/j.jconrel.2022.12.028. Epub 2022 Dec 15.
With the development of nanotechnology, nanomedicines are widely used in tumor therapy. However, biological barriers in the delivery of nanoparticles still limit their application in tumor therapy. As one of the most fundamental properties of nanoparticles, particle size plays a crucial role in the process of the nanoparticles delivery process. It is difficult for large size nanoparticles with fixed size to achieve satisfactory outcomes in every process. In order to overcome the poor penetration of larger size, nanoparticles with ultra-small particle size are proposed, which are more conducive to deep tumor penetration and uniform drug distribution. In this review, the latest progresses and advantages of ultra-small nanoparticles are systematically summarized, the perspectives and challenges of ultra-small nanoparticles strategy for cancer treatment are also discussed.
随着纳米技术的发展，纳米药物在肿瘤治疗中得到广泛应用。然而，纳米颗粒递送过程中的生物屏障仍然限制了它们在肿瘤治疗中的应用。作为纳米颗粒最基本的性质之一，粒径在纳米颗粒递送过程中起着至关重要的作用。固定尺寸的大尺寸纳米颗粒很难在每个过程中都取得令人满意的效果。为了克服大尺寸纳米颗粒穿透性差的问题，人们提出了超小粒径的纳米颗粒，其更有利于深入肿瘤组织并实现药物均匀分布。在这篇综述中，系统地总结了超小纳米颗粒的最新进展和优势，还讨论了超小纳米颗粒用于癌症治疗策略的前景和挑战。
