Carré Chloé, Acar Niyazi, Daruich Alejandra, Grégoire Stéphane, Martine Lucy, Buteau Bénédicte, Aho Serge, Eid Petra, Arnould Louis, Bron Alain Marie, Driessen Marine, Kermorvant Elsa, Simon Emmanuel, Creuzot-Garcher Catherine, Gabrielle Pierre-Henry
Department of Ophthalmology, Dijon University Hospital, 14 Rue Paul Gaffarel, 21000, Dijon, France.
Eye and Nutrition Research Group, Centre Des Sciences du Goût Et de L'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Dijon, France.
BMC Ophthalmol. 2023 Oct 6;23(1):404. doi: 10.1186/s12886-023-03156-0.
Incomplete vascularization of the retina in preterm infants carries a risk of retinopathy of prematurity (ROP). Progress in neonatal resuscitation in developing countries has led to the survival of an increasing number of premature infants, resulting in an increased rate of ROP and consequently in visual disability. Strategies to reduce ROP involve optimizing oxygen saturation, nutrition, and normalizing factors such as insulin-like growth factor 1 and n-3 long-chain polyunsaturated fatty acids (LC-PUFA). Our previous study, OmegaROP, showed that there is an accumulation or retention of docosahexaenoic acid (DHA) in mothers of infants developing ROP, suggesting abnormalities in the LC-PUFA placental transfer via fatty acid transporting proteins. The present study aims to better understand the LC-PUFA transport dysfunction in the fetoplacental unit during pregnancy and to find a novel target for the prevention of ROP development.
The study protocol is designed to evaluate the correlation between the expression level of placental fatty acid receptors and ROP occurrence. This ongoing study will include 100 mother-infant dyads: mother-infant dyads born before 29 weeks of gestational age (GA) and mother-infant dyads with full-term pregnancies. Recruitment is planned over a period of 46 months. Maternal and cord blood samples as well as placental tissue samples will be taken following delivery. ROP screening will be performed using wide-field camera imaging according to the International Classification of ROP consensus statement.
The results of this study will have a tangible impact on public health. Indeed, if we show a correlation between the expression level of placental omega-3 receptors and the occurrence of ROP, it would be an essential step in discovering novel pathophysiological mechanisms involved in this retinopathy.
NCT04819893.
早产儿视网膜血管化不完全存在发生早产儿视网膜病变（ROP）的风险。发展中国家新生儿复苏技术的进步使越来越多的早产儿存活下来，导致ROP发病率上升，进而导致视力残疾。降低ROP的策略包括优化氧饱和度、营养状况，以及使胰岛素样生长因子1和n-3长链多不饱和脂肪酸（LC-PUFA）等因素正常化。我们之前的OmegaROP研究表明，患ROP婴儿的母亲体内二十二碳六烯酸（DHA）存在蓄积或潴留现象，这表明通过脂肪酸转运蛋白进行的LC-PUFA胎盘转运存在异常。本研究旨在更好地了解孕期胎儿-胎盘单位中LC-PUFA的转运功能障碍，并寻找预防ROP发展的新靶点。
本研究方案旨在评估胎盘脂肪酸受体表达水平与ROP发生之间的相关性。这项正在进行的研究将纳入100对母婴：孕龄小于29周出生的母婴对以及足月妊娠的母婴对。计划在46个月内完成招募。分娩后采集母体和脐带血样本以及胎盘组织样本。将根据ROP国际分类共识声明，使用广角相机成像进行ROP筛查。
本研究结果将对公共卫生产生切实影响。事实上，如果我们证明胎盘ω-3受体的表达水平与ROP的发生之间存在相关性，这将是发现这种视网膜病变所涉及的新病理生理机制的关键一步。
NCT04819893。
