College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates, United Arab Emirates.
AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, United Arab Emirates.
Expert Rev Anti Infect Ther. 2023 Jul-Dec;21(12):1281-1286. doi: 10.1080/14787210.2023.2268835. Epub 2023 Nov 24.
Antibiotic consumption rates are high in both high and low-income countries, but addressing antibiotic practices in low- and middle-income countries (LMICs) is crucial to combatting antibiotic resistance (AR).
This editorial examines the current landscape of antibiotic practices in LMICs, investigate the factors driving such trends including lack of resource equity and shared global responsibility, and explore (AR) global implications, with particular emphasis placed on swift measures to combat its spread.
LMICs face three key obstacles that exacerbate AR: inadequate WASH services, climate factors, and misuse of antibiotics. A lack of sanitation and clean water promotes infections, while poor hygiene exacerbates resistant pathogen spread. Global strategies should go beyond simply educating LMICs about antibiotic misuse; they must also understand its repercussions, such as prolonged illnesses and drug-resistant bacteria like MRSA. Addressing this challenge requires multifaceted strategies, including improving WASH services, acknowledging climate impacts, and tightening regulations. Prioritizing WASH requires significant funding, community participation, technology solutions, and partnerships with NGOs. Utilizing social media influencers can boost AR awareness. Antibiotic regulation reforms, manufacturing quality, and seeking antibiotic alternatives are vital. Antimicrobial Stewardship Programs and AI's potential in managing resistant infections are notable.
高收入和低收入国家的抗生素使用率都很高，但解决低收入和中等收入国家（LMICs）的抗生素使用问题对于对抗抗生素耐药性（AR）至关重要。
本社论审视了 LMICs 目前的抗生素使用情况，调查了推动这些趋势的因素，包括资源公平和全球共同责任的缺失，并探讨了（AR）的全球影响，特别强调了迅速采取措施来遏制其传播。
LMICs 面临着加剧 AR 的三个关键障碍：卫生和清洁用水服务不足、气候因素以及抗生素的滥用。缺乏卫生和清洁水会促进感染，而不良的卫生习惯会加剧耐药病原体的传播。全球战略不仅要简单地教育 LMICs 如何正确使用抗生素，还要了解其后果，如延长疾病和耐甲氧西林金黄色葡萄球菌（MRSA）等耐药细菌的传播。应对这一挑战需要采取多方面的策略，包括改善卫生和清洁用水服务、认识到气候影响以及加强法规。优先考虑卫生和清洁用水需要大量资金、社区参与、技术解决方案以及与非政府组织的合作。利用社交媒体影响者可以提高对抗生素耐药性的认识。抗生素监管改革、制造质量和寻找抗生素替代品至关重要。抗生素管理计划和人工智能在管理耐药感染方面的潜力值得关注。
