Department of Biological Chemistry and Pharmacology, College of Medicine, Ohio State University, Columbus, Ohio, USA.
Comprehensive Cancer Center, Wexner Medical Center, Arthur G. James Cancer Hospital, Ohio State University, Columbus, Ohio, USA.
J Gerontol A Biol Sci Med Sci. 2024 Feb 1;79(2). doi: 10.1093/gerona/glad239.
The geroscience hypothesis suggests that addressing the fundamental mechanisms driving aging biology will prevent or mitigate the onset of multiple chronic diseases, for which the largest risk factor is advanced age. Research that investigates the root causes of aging is therefore of critical importance given the rising healthcare burden attributable to age-related diseases. The third annual Midwest Aging Consortium symposium was convened as a showcase of such research performed by investigators from institutions across the Midwestern United States. This report summarizes the work presented during a virtual conference across topics in aging biology, including immune function in the lung-particularly timely given the Corona Virus Immune Disease-2019 pandemic-along with the role of metabolism and nutrient-regulated pathways in cellular function with age, the influence of senescence on stem cell function and inflammation, and our evolving understanding of the mechanisms underlying observation of sex dimorphism in aging-related outcomes. The symposium focused on early-stage and emerging investigators, while including keynote presentations from leaders in the biology of aging field, highlighting the diversity and strength of aging research in the Midwest.
衰老科学假说表明，解决导致衰老生物学的基本机制将预防或减轻多种慢性疾病的发生，而这些疾病的最大风险因素是年龄增长。鉴于与年龄相关的疾病导致的医疗保健负担不断增加，因此，研究衰老的根本原因至关重要。第三届中西部衰老联盟研讨会的召开旨在展示来自美国中西部地区各机构的研究人员进行的此类研究。本报告总结了在一次虚拟会议上介绍的衰老生物学相关主题的工作，包括肺部的免疫功能——鉴于当前的 2019 年冠状病毒疾病大流行，这一主题尤其及时——以及代谢和营养调节途径在衰老过程中对细胞功能的作用、衰老对干细胞功能和炎症的影响，以及我们对观察到的衰老相关结果中的性别二态性的机制的不断深入理解。该研讨会侧重于处于早期阶段和新兴的研究人员，同时包括衰老生物学领域的领导者的主题演讲，突出了中西部地区衰老研究的多样性和实力。
