从肺动脉高压患者中生成两个诱导多能干细胞系。
Generation of two induced pluripotent stem cell lines from patients suffering from pulmonary hypertension.
机构信息
Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Human Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Stem Cell Res. 2023 Oct;72:103218. doi: 10.1016/j.scr.2023.103218. Epub 2023 Sep 30.
Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease, with an estimated 500-1000 new cases diagnosed every year. A portion of these cases may be caused by mutations in the BMPR2 gene, suggesting a possible genetic component in the development of the disease. Here, we report two human induced pluripotent stem cell (iPSC) lines generated from IPAH patients. Both cell lines provide valuable insight into the molecular and cellular mechanisms of IPAH and can be used to further understand the disease.
特发性肺动脉高压（IPAH）是一种罕见疾病，每年估计有 500-1000 例新病例被诊断出来。这些病例中的一部分可能是由 BMPR2 基因突变引起的，这表明该疾病的发生可能存在遗传因素。在这里，我们报告了从 IPAH 患者中生成的两个人类诱导多能干细胞（iPSC）系。这两个细胞系为 IPAH 的分子和细胞机制提供了有价值的见解，并可用于进一步了解该疾病。
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