[脂蛋白电泳在血浆脂蛋白定量评估中的价值]
[Value of lipoprotein electrophoresis for the quantitative assessment of plasma lipoproteins].
作者信息
Breier C, Lisch H J, Drexel H, Braunsteiner H
出版信息
Dtsch Med Wochenschr. 1986 Dec 5;111(49):1888-90. doi: 10.1055/s-2008-1068730.
The reliability of semiquantitative densitometric lipoprotein electrophoresis was compared with that of the quantitative determination of plasma lipoproteins by zonal ultracentrifugation on plasma from 73 patients. As an alternative to the measurement of lipoproteins by electrophoresis other, simple laboratory methods were used and also compared with plasma lipoprotein concentrations obtained by zonal ultracentrifugation. It was found that quantitative measurement of plasma lipoproteins by densitometric electrophoresis correlated positively to actual plasma concentration by zonal ultracentrifugation, but other simple methods of lipid determination--of plasma cholesterol; of triglycerides; of HDL and LDL cholesterol--are definitely better for obtaining plasma lipoprotein concentrations. Lipoprotein electrophoresis should not be used for the quantitative determination of plasma lipoproteins.
对73例患者血浆进行了研究，比较了半定量密度脂蛋白电泳与区带超速离心法定量测定血浆脂蛋白的可靠性。作为脂蛋白电泳测量的替代方法，还使用了其他简单的实验室方法，并将其与区带超速离心法测得的血浆脂蛋白浓度进行比较。结果发现，密度电泳法定量测定血浆脂蛋白与区带超速离心法测得的实际血浆浓度呈正相关，但其他简单的血脂测定方法——血浆胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白胆固醇的测定——在获取血浆脂蛋白浓度方面肯定更好。脂蛋白电泳不应被用于血浆脂蛋白的定量测定。
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