Department of PG Studies and Research in Applied Zoology, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Karnataka 577451, India.
Department of PG Studies and Research in Applied Zoology, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Karnataka 577451, India.
Neurotoxicol Teratol. 2023 Nov-Dec;100:107305. doi: 10.1016/j.ntt.2023.107305. Epub 2023 Oct 5.
Clobazam (CLB) and Vigabatrin (VGB) are the two widely used Antiepileptic drugs, which may have teratogenic potentiality and it has been evaluated in the fruit fly Drosophila melanogaster. These different concentrations of CLB (0.156, 0.25, and 0.312 μg/ml) and VGB (17.6, 22, and 44 μg/ml) were used to evaluate the life-history parameters, developmental, and behavioral abnormalities. The results revealed that life-history parameters (fecundity, fertility, larval and pupal mortality) were significantly affected along with varied developmental duration, and pupal and adult deformities in flies on exposure of CLB and VGB in concentration dependent manner. The present study demonstrated that the prenatal treatment of CLB and VGB has displayed clear teratogenic potentiality with various deformities in the fruit fly. The findings could be correlated with the various abnormalities in human caused by the use of AEDs.
氯巴占（CLB）和氨己烯酸（VGB）是两种广泛使用的抗癫痫药物，它们可能具有致畸潜力，并已在黑腹果蝇中进行了评估。这些不同浓度的 CLB（0.156、0.25 和 0.312μg/ml）和 VGB（17.6、22 和 44μg/ml）用于评估生活史参数、发育和行为异常。结果表明，生活史参数（繁殖力、生育率、幼虫和蛹死亡率）随着 CLB 和 VGB 浓度的变化而显著受到影响，并且在暴露于 CLB 和 VGB 时，果蝇的发育持续时间、蛹和成虫畸形也发生了变化。本研究表明，CLB 和 VGB 的产前处理表现出明显的致畸潜力，导致果蝇出现各种畸形。这些发现可能与抗癫痫药物使用引起的人类各种异常有关。
