Gao L, Jin L F, Chen G D
School of Public Health, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2023 Sep 20;41(9):710-714. doi: 10.3760/cma.j.cn121094-20220513-00259.
Previous epidemiological studies suggested that occupational antimony exposure was associated with an increased risk of lung cancer. The evidence is sufficient for carcinogenicity of trivalent antimony in experimental animals, and strong mechanistic evidence has been observed in human primary cells and experinental systems. Thus, trivalent antimony has been classified as possibly carcinogenic to humans (Group 2A) by International Agency for Research on Cancer (IARC) , and the United States National Toxicology Program (NTP) classified Sb(2)O(3) as a human carcinogen. Antimony and its compounds could induce chromosome breakage and/or DNA damage. Oxidative damage of DNA under oxidative stress and inhibition of DNA damage repair may be the main mechanism of antimony carcinogenesis. This review summarizes the epidemiological investigation of occupational antimony exposure and lung cancer, as well as the experimental research progression on the carcinogenic effects of antimony exposure, and discusses the limitations of previous studies and future research directions.
以往的流行病学研究表明，职业性锑暴露与肺癌风险增加有关。有充分证据表明三价锑在实验动物中具有致癌性，并且在人类原代细胞和实验系统中也观察到了有力的机制证据。因此，国际癌症研究机构（IARC）已将三价锑归类为对人类可能致癌（2A组），美国国家毒理学计划（NTP）将Sb₂O₃归类为人类致癌物。锑及其化合物可诱导染色体断裂和/或DNA损伤。氧化应激下DNA的氧化损伤以及DNA损伤修复的抑制可能是锑致癌的主要机制。本综述总结了职业性锑暴露与肺癌的流行病学调查，以及锑暴露致癌作用的实验研究进展，并讨论了以往研究的局限性和未来的研究方向。
