Lee S J, Nathans D
Endocrinology. 1987 Jan;120(1):208-13. doi: 10.1210/endo-120-1-208.
Proliferin (PLF) is a member of the PRL-GH family whose mRNA has been detected in proliferating mouse cells in culture and in mouse placenta. Suspensions of murine placental tissue have been shown to produce PLF detectable by immunoprecipitation. Here we report that PLF is secreted as a heterogeneous glycoprotein by growing mouse cell lines and placental tissue and that the first 29 amino acids of the preprotein serve as a signal peptide. Placental PLF is immunologically distinguishable from the 2 previously described mouse placental lactogens.
增殖蛋白（PLF）是催乳素-生长激素（PRL-GH）家族的成员，其信使核糖核酸（mRNA）已在培养的增殖小鼠细胞和小鼠胎盘中检测到。小鼠胎盘组织悬液已被证明能产生可通过免疫沉淀检测到的PLF。在此我们报告，PLF由生长中的小鼠细胞系和胎盘组织分泌为一种异质性糖蛋白，并且前体蛋白的前29个氨基酸作为信号肽。胎盘PLF在免疫学上与先前描述的两种小鼠胎盘催乳素不同。
