Fujisawa T, Hongo H, Yamaguchi Y, Shiba M, Kadoyama C, Kawano Y, Fukasawa T
Endoscopy. 1986 Sep;18(5):188-91. doi: 10.1055/s-2007-1018369.
We performed intratumoral ethanol injection via a flexible bronchofiberscope in 13 patients with malignant tracheobronchial lesions in order to evaluate its effects on airway dilatation and hemostasis. The results obtained are described below. Immediately after intratumoral injection of ethanol, bronchofiberscopic findings revealed that the tumor turned faintly white, there was a little regression of tumor, and a promising effect was demonstrated on patients with bleeding from tumors. The injected tumor turned necrotic within several days, and histological examination revealed no viable tumor cells in necrotic tissues. The histological anti-tumor effect of ethanol was also demonstrated in experiments with nude mice. This endoscopic treatment was very effective in polypoid tumor protruding into the tracheobronchial lumen, but ineffective in the case of compressed stenosis or obstruction. In conclusion, intratumoral injection of ethanol is considered to be a promising endoscopic treatment for malignant tracheobronchial lesions.
我们通过可弯曲纤维支气管镜对13例气管支气管恶性病变患者进行瘤内乙醇注射，以评估其对气道扩张和止血的效果。现将所得结果描述如下。瘤内注射乙醇后立即进行纤维支气管镜检查，结果显示肿瘤颜色变淡呈白色，肿瘤稍有缩小，且对肿瘤出血患者显示出良好疗效。注射乙醇后的肿瘤在数天内坏死，组织学检查显示坏死组织中无存活肿瘤细胞。乙醇的组织学抗肿瘤作用在裸鼠实验中也得到证实。这种内镜治疗方法对突入气管支气管腔内的息肉样肿瘤非常有效，但对受压狭窄或阻塞的情况无效。总之，瘤内注射乙醇被认为是一种有前景的气管支气管恶性病变内镜治疗方法。
