与长期空气污染暴露相关的多发性骨髓瘤风险——四个欧洲队列的汇总分析。

Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts.

机构信息

The Danish Cancer Institute, Copenhagen, Denmark.

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

出版信息

Environ Res. 2023 Dec 15;239(Pt 1):117230. doi: 10.1016/j.envres.2023.117230. Epub 2023 Oct 6.

DOI:10.1016/j.envres.2023.117230

PMID:37806476

Abstract

BACKGROUND

Air pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated.

METHODS

We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO), fine particles (PM), black carbon (BC), and ozone (O) and multiple myeloma. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.

RESULTS

During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO, 1.04 (0.82, 1.33) per 5 μg/m³ PM, 0.99 (0.84, 1.18) per 0.5 10 m BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O.

CONCLUSIONS

We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.

摘要

背景

空气污染是一个全球性的问题，对人类健康有重大影响。多发性骨髓瘤是一种发病率不断上升的血液癌。研究表明，空气污染暴露与多种癌症有关，包括白血病和淋巴瘤，但与多发性骨髓瘤发病率的关系尚未得到广泛研究。

方法

我们汇总了四个欧洲队列（N=234803），评估了居住环境中二氧化氮（NO）、细颗粒物（PM）、黑碳（BC）和臭氧（O）暴露与多发性骨髓瘤之间的关系。我们应用 Cox 比例风险模型，在个体和地区层面上调整了潜在的混杂因素。

结果

在 4415817 人年的随访期间（平均 18.8 年），我们观察到 404 例多发性骨髓瘤病例。完全调整的线性分析结果显示，每 10μg/m³NO、每 5μg/m³PM、每 0.510m BCE 增加 0.99（0.84，1.16）、每 10μg/m³O 增加 1.11（0.87，1.41）的风险比（95%置信区间）。