Sigurdsson G H
Eur J Anaesthesiol. 1986 Mar;3(2):87-94.
The author studied the rate of induction and recovery, occurrence of airway problems and the degree of respiratory depression in 30 children breathing spontaneously during inhalational induction for intubation. Two equi-anaesthetic gas mixtures were compared, 5.0% enflurane in 50% N2O (group E50) and 3.2% enflurane in 70% N2O (group E70). Induction time and time for 'partial recovery' were significantly shorter in group E70 than in group E50 (P less than 0.05). Airway problems during the excitational stage and during intubation were less common in group E70 than in group E50 (P less than 0.05). Also respiratory depression, as measured by end-tidal CO2 tension and by the occurrence of apnoea, was significantly less pronounced in group E70 than in group E50. It was concluded that 3.2% enflurane-N2O/O2 (70/30) was quite acceptable for mask induction for intubation in spontaneously breathing children, while 5.0% enflurane-N2O/O2 (50/50) caused a marked respiratory depression with delayed induction and offered less suitable conditions for intubation.
作者研究了30例在吸入诱导插管期间自主呼吸的儿童的诱导和恢复速度、气道问题的发生情况以及呼吸抑制程度。比较了两种等效麻醉气体混合物，50%氧化亚氮中含5.0%安氟醚（E50组）和70%氧化亚氮中含3.2%安氟醚（E70组）。E70组的诱导时间和“部分恢复”时间明显短于E50组（P<0.05）。E70组兴奋期和插管期间的气道问题比E50组少见（P<0.05）。此外，通过呼气末二氧化碳分压和呼吸暂停的发生情况衡量的呼吸抑制，E70组也明显比E50组轻。得出的结论是，3.2%安氟醚-氧化亚氮/氧气（70/30）对于自主呼吸儿童面罩诱导插管是相当合适的，而5.0%安氟醚-氧化亚氮/氧气（50/50）会导致明显的呼吸抑制，诱导延迟，且为插管提供的条件不太合适。
