Lesne M, Clerckx-Braun F, Duhoux P, van Ypersele de Strihou C
Int J Clin Pharmacol Ther Toxicol. 1982 Aug;20(8):382-7.
A new diuretic drug, torasemide, after oral or i. v. administration of 20 mg to six normal volunteers showed good bioavailability (greater than 91%). Its biologic half-life is about 2.5 h with a distribution volume of 180 ml/kg and a body clearance of 0.8 ml/min kg. The renal excretion represents only 25% of the total drug elimination. The excretion of water, sodium, potassium, and chloride parallels the renal excretion of torasemide. The diuretic action has a duration of 6 h, reaching its maxima during the 1st h after i. v. administration an during the 2nd h after oral administration.
一种新型利尿药托拉塞米，给6名正常志愿者口服或静脉注射20毫克后，显示出良好的生物利用度（大于91%）。其生物半衰期约为2.5小时，分布容积为180毫升/千克，机体清除率为0.8毫升/分钟·千克。肾脏排泄仅占药物总消除量的25%。水、钠、钾和氯的排泄与托拉塞米的肾脏排泄平行。利尿作用持续6小时，静脉注射后第1小时和口服后第2小时达到最大值。
