Ren Tao, Yang Meng-Zhe, Zhang Wei-Ming, Qin Liu-Jie, Zhou Shou-Chang, Cheng Nan-Nan, Huang Yuan-Jiao, Sun Jing, Xu Ning, Sun Hua-Bing, Zhang Bei-Bei
Department of Clinical Oncology, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China.
Graduate School, Beijing TongRen Hospital, Capital Medical University, Beijing 100069, P.R. China.
Oncol Lett. 2023 Sep 20;26(5):472. doi: 10.3892/ol.2023.14058. eCollection 2023 Nov.
Numerous agents such as near-infrared dyes that are characterized by specialized cancer imaging and cytotoxicity effects have key roles in cancer diagnosis and therapy via molecularly targeting special biological tissues, organelles and processes. In the present study, a novel fluorescent compound was demonstrated to inhibit cancer cell proliferation in a zebrafish model with slight toxicity. Further studies demonstrated selective staining of cancer cells and even putative cancer stem cells via accumulation of the dye in the mitochondria of cancer cells, compared with normal cells. Moreover, this compound was also used to image cancer cells using a zebrafish model. The compound displayed no apparent toxicity to the host animal. Overall, the data indicated that this compound was worthy of further evaluation due to its low toxicity and selective cancer cell imaging and killing effects. It could be a useful tool in cancer research.
许多具有特殊癌症成像和细胞毒性作用的试剂，如近红外染料，通过分子靶向特殊的生物组织、细胞器和过程，在癌症诊断和治疗中发挥着关键作用。在本研究中，一种新型荧光化合物在斑马鱼模型中被证明具有轻微毒性并能抑制癌细胞增殖。进一步研究表明，与正常细胞相比，该染料通过在癌细胞线粒体中积累，对癌细胞甚至假定的癌症干细胞具有选择性染色作用。此外，该化合物还被用于利用斑马鱼模型对癌细胞进行成像。该化合物对宿主动物无明显毒性。总体而言，数据表明该化合物因其低毒性以及选择性癌细胞成像和杀伤作用而值得进一步评估。它可能是癌症研究中的一种有用工具。
