McIntyre D C, Stokes K A, Edson N
Exp Neurol. 1986 Dec;94(3):554-70. doi: 10.1016/0014-4886(86)90237-2.
Status epilepticus of either a nonconvulsive, partial, or generalized form was provoked in rats by 60 min of electrical stimulation of a kindled focus in the posterior-ventral hippocampus. Following spontaneous offset of the nonconvulsive status epilepticus, minor pathology occurred which was largely restricted to the hippocampus, whereas partial or generalized status epilepticus produced considerable bilateral damage in the hippocampus, basolateral amygdala, and pyriform cortex. Bisection of the anterior half of the corpus callosum lateralized the forelimb motor seizures and bisection of the hippocampal commissure lateralized the hippocampal afterdischarge and the associated brain pathology. Paradoxically, commissurotomy also increased the probability of developing status epilepticus while reducing its severity. Further, it was shown that the right hippocampus precipitated status epilepticus with a higher probability than the left hippocampus in both intact and split-brain rats.
通过对大鼠后腹侧海马的点燃灶进行60分钟的电刺激，诱发非惊厥性、部分性或全身性癫痫持续状态。在非惊厥性癫痫持续状态自发缓解后，出现了轻微的病理变化，主要局限于海马体，而部分性或全身性癫痫持续状态则在海马体、基底外侧杏仁核和梨状皮质造成了相当大的双侧损伤。胼胝体前半部分的横断使前肢运动性癫痫发作侧化，海马连合的横断使海马后放电及相关脑病理变化侧化。矛盾的是，连合切开术在降低癫痫持续状态严重程度的同时，也增加了其发生的概率。此外，研究表明，在完整大鼠和裂脑大鼠中，右侧海马诱发癫痫持续状态的概率均高于左侧海马。
