McIntyre D C, Stenstrom R J, Taylor D, Stokes K A, Edson N
Physiol Behav. 1985 Jan;34(1):133-9. doi: 10.1016/0031-9384(85)90091-5.
In experiment 1, electrical stimulation of the posterior hippocampus was shown to produce state-dependent learning (SDL) for a step-out inhibitory avoidance task in rats. Stimulation sites in either the right or left hippocampus were equally effective in producing this effect. Similarly, the presence or absence of afterdischarge (AD) following the stimulation did not differentially affect performance on the task. In experiment 2, forebrain bisection ameliorated the behavioral deficits in the animals receiving stimulation before testing but not before training (N/S group), while those stimulated before training but not before testing (S/N group) remained impaired; thus, providing a demonstration of asymmetrical SDL. Variations in extent of the commissurotomy differentially affected the laterality of the afterdischarge but not the performance in the SDL task. Speculation as to the mechanisms of this SDL effect was presented.
在实验1中，对大鼠后海马体进行电刺激被证明可产生用于一步跳出抑制性回避任务的状态依赖性学习（SDL）。右侧或左侧海马体中的刺激位点在产生这种效应方面同样有效。同样，刺激后是否存在后放电（AD）对该任务的表现没有差异影响。在实验2中，前脑切断改善了在测试前但非训练前接受刺激的动物（N/S组）的行为缺陷，而在训练前但非测试前接受刺激的动物（S/N组）仍然受损；因此，证明了不对称的SDL。连合切开范围的变化对后放电的偏侧性有不同影响，但对SDL任务的表现没有影响。文中还对这种SDL效应的机制进行了推测。
