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登革热与低钾性麻痹:一种罕见的关联。

Dengue and Hypokalemic Paralysis: A Rare Association.

作者信息

Akhtar Ujala, Mushtaq Muhammad Hamza, Nisar Sarah, Naeem Awais, Naim Fahad

机构信息

Medicine, Khyber Teaching Hospital, Peshawar, PAK.

Internal Medicine, Lady Reading Hospital, Peshawar, PAK.

出版信息

Cureus. 2023 Sep 5;15(9):e44705. doi: 10.7759/cureus.44705. eCollection 2023 Sep.

DOI:10.7759/cureus.44705
PMID:37809211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10552571/
Abstract

Dengue is one of the most common mosquito-borne viral illnesses in tropical areas, including Pakistan. Presentation varies from a self-limiting flu-like illness to life-threatening conditions like hemorrhagic shock and multi-organ dysfunction leading to death. In the absence of vomiting and diarrhea, electrolyte abnormalities are rare findings. Though Guillain-Barré syndrome is a known association of viral illnesses presenting with flaccid paralysis, there is a possibility for dengue to cause hypokalemia without apparent gut or renal losses. Dengue-associated hypokalemic paralysis is an underrecognized entity but has a favorable outcome. The clinician should suspect this in patients presenting with motor weakness in dengue-endemic areas. Neurological complications of dengue are reported frequently now, so early recognition of these neurological manifestations is needed for the successful recovery of patients. Here, we discuss a case of dengue-induced hypokalemia presenting with acute flaccid paralysis.

摘要

登革热是包括巴基斯坦在内的热带地区最常见的蚊媒病毒性疾病之一。其临床表现多样,从自限性的流感样疾病到危及生命的情况,如出血性休克和导致死亡的多器官功能障碍。在没有呕吐和腹泻的情况下,电解质异常是罕见的发现。虽然吉兰 - 巴雷综合征是已知的与表现为弛缓性麻痹的病毒性疾病相关的病症,但登革热有可能在没有明显肠道或肾脏失钾的情况下导致低钾血症。登革热相关的低钾性麻痹是一个未被充分认识的实体,但预后良好。在登革热流行地区出现运动无力的患者中,临床医生应怀疑此病。现在登革热的神经并发症报道频繁,因此为了患者的成功康复,需要早期识别这些神经表现。在此,我们讨论一例登革热诱发低钾血症并伴有急性弛缓性麻痹的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d978/10552571/a346f3dea3a7/cureus-0015-00000044705-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d978/10552571/25ea310f8c0d/cureus-0015-00000044705-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d978/10552571/a346f3dea3a7/cureus-0015-00000044705-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d978/10552571/25ea310f8c0d/cureus-0015-00000044705-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d978/10552571/a346f3dea3a7/cureus-0015-00000044705-i02.jpg

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本文引用的文献

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Neurological Manifestations of Dengue Fever.登革热的神经学表现
Ann Indian Acad Neurol. 2021 Sep-Oct;24(5):693-702. doi: 10.4103/aian.AIAN_157_21. Epub 2021 May 28.
2
Correlation of serotype-specific strain in patients with dengue virus infection with neurological manifestations and its outcome.登革热病毒感染患者的血清型特异性株与神经表现及其结局的相关性。
Neurol Sci. 2022 Mar;43(3):1939-1946. doi: 10.1007/s10072-021-05477-8. Epub 2021 Aug 2.
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Dengue, Guillain-Barré Syndrome, and Cerebral Infarction: A Case of Rare Complication.
登革热、吉兰-巴雷综合征与脑梗死:一例罕见并发症病例
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Hypokalemic Quadriparesis: A Rare Manifestation of Dengue Fever.低钾性四肢瘫:登革热的一种罕见表现
Ann Indian Acad Neurol. 2019 Oct-Dec;22(4):519-520. doi: 10.4103/aian.AIAN_512_18. Epub 2019 Oct 25.
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[Dengue fever : Symptoms, epidemiology, entomology, pathogen diagnosis and prevention].[登革热:症状、流行病学、昆虫学、病原体诊断与预防]
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Neurological Manifestations of Dengue Infection.登革热感染的神经表现。
Front Cell Infect Microbiol. 2017 Oct 25;7:449. doi: 10.3389/fcimb.2017.00449. eCollection 2017.
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Rapidly Resolving Weakness Related to Hypokalemia in Patients Infected With Dengue Virus.登革病毒感染患者中与低钾血症相关的快速缓解性肌无力
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Guillain-Barre syndrome following dengue fever and literature review.登革热后吉兰-巴雷综合征及文献综述
BMC Res Notes. 2015 Nov 27;8:729. doi: 10.1186/s13104-015-1672-0.
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Dengue-associated neuromuscular complications.登革热相关的神经肌肉并发症。
Neurol India. 2015 Jul-Aug;63(4):497-516. doi: 10.4103/0028-3886.161990.
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An unusual case of dengue infection presenting with hypokalemic paralysis with hypomagnesemia.一种不常见的登革热感染病例,表现为低钾性瘫痪伴低镁血症。
J Clin Virol. 2015 Aug;69:197-9. doi: 10.1016/j.jcv.2015.06.098. Epub 2015 Jun 26.