Tan Hannah, Torere Beatrice E, Okun Sherry, Hinton Benjamin
Hematology and Oncology, East Tennessee State University, Johnson City, USA.
Internal Medicine, North Mississippi Medical Center, Tupelo, USA.
Cureus. 2023 Sep 5;15(9):e44724. doi: 10.7759/cureus.44724. eCollection 2023 Sep.
Non-small cell lung cancer (NSCLC) is the dominant form of lung cancer, comprising around 85% of cases. Stage 4 NSCLC has a grim prognosis; however, immunotherapy and radiation therapy have become vital treatments for advanced-stage NSCLC, despite the risk of inducing a second primary malignancy. This case report focuses on a 45-year-old female diagnosed with NSCLC and metastasis to the 11th thoracic vertebral body. After various treatments, including radiation, a potential radiation-associated secondary malignancy, epithelial angiosarcoma, was discovered. Following treatment modification, the patient achieved complete metabolic remission, highlighting the importance of clinicians being cautious about secondary primary cancers in NSCLC patients with a history of radiation therapy. Accurate diagnosis through biopsy and continuous surveillance are essential in managing NSCLC patients effectively.
非小细胞肺癌（NSCLC）是肺癌的主要形式，约占所有病例的85%。IV期非小细胞肺癌预后严峻；然而，尽管存在诱发第二原发性恶性肿瘤的风险，但免疫疗法和放射疗法已成为晚期非小细胞肺癌的重要治疗方法。本病例报告聚焦于一名45岁女性，她被诊断为非小细胞肺癌并已转移至第11胸椎椎体。在接受包括放疗在内的各种治疗后，发现了一种潜在的与放疗相关的继发性恶性肿瘤——上皮样血管肉瘤。经过治疗调整，患者实现了完全代谢缓解，这凸显了临床医生对于有放疗史的非小细胞肺癌患者发生第二原发性癌症保持谨慎的重要性。通过活检进行准确诊断并持续监测对于有效管理非小细胞肺癌患者至关重要。
