The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs.

. To evaluate carotid artery intima-media thickness (CIMT) and lipid profile in children with epilepsy on long-term antiepileptic drug (AED) monotherapy. . We included 60 children with epilepsy receiving valproate, carbamazepine, or levetiracetam monotherapy and 60 controls. A high-resolution B-mode ultrasound was used to measure (CIMT). Measurement of serum lipids was done. . Patients on valproate (0.44 ± 0.03,  ≤ .001), carbamazepine (0.43 ± 0.03with  ≤ .001), and levetiracetam (0.44 ± 0.02 with  ≤ .001) monotherapy showed significantly higher CIMT compared to controls. CIMT was correlated with age ( = .041,  = .112) AEDs{valproate ( = .005,  = .731), carbamazepine ( = .038,  = .365), and levetiracetam ( = .036,  = .155)}, duration of treatment ( = .001,  = .313), TC( = .001,  = .192), TG ( = .014,  = .018), and LDL ( = .001,  = .219). HDL ( = .003,  = -.126). Seizure severity and Apo A1 were insignificantly involved. . Long-term monotherapy with valproate, carbamazepine, and levetiracetam in epileptic children was associated with significant abnormalities in CIMT.