Baroncini Liz Andréa Villela, Sylvestre Lucimary de Castro, Pecoits Filho Roberto
Pontifícia Universidade Católica do Paraná, PR, Brazil.
Arq Bras Cardiol. 2016 Apr;106(4):327-32. doi: 10.5935/abc.20160030. Epub 2016 Mar 8.
Carotid intima-media thickness (CIMT) has been shown to be increased in children and adolescents with traditional cardiovascular risk factors such as obesity, hypertension, and chronic kidney disease, compared with those of healthy children.
To assess the influence of sex, age and body mass index (BMI) on the CIMT in healthy children and adolescents aged 1 to 15 years.
A total of 280 healthy children and adolescents (males, n=175; mean age, 7.49±3.57 years; mean BMI, 17.94±4.1 kg/m2) were screened for CIMT assessment. They were divided into 3 groups according to age: GI, 1 to 5 years [n=93 (33.2%); males, 57; mean BMI, 16±3 kg/m2]; GII, 6 to 10 years [n=127 (45.4%); males, 78; mean BMI, 17.9±3.7 kg/m2], and GIII, 11 to 15 years [n=60 (21.4%); males, 40; mean BMI, 20.9±4.5 kg/m2].
There was no significant difference in CIMT values between male and female children and adolescents (0.43±0.06 mm vs. 0.42±0.05 mm, respectively; p=0.243). CIMT correlated with BMI neither in the total population nor in the 3 age groups according to Pearson correlation coefficient. Subjects aged 11 to 15 years had the highest CIMT values (GI vs. GII, p=0.615; GI vs. GIII, p=0.02; GII vs. GIII, p=0.004).
CIMT is constant in healthy children younger than 10 years, regardless of sex or BMI. CIMT increases after the age of 10 years.
与健康儿童相比，患有肥胖、高血压和慢性肾病等传统心血管危险因素的儿童和青少年的颈动脉内膜中层厚度（CIMT）已被证实有所增加。
评估性别、年龄和体重指数（BMI）对1至15岁健康儿童和青少年CIMT的影响。
共筛选了280名健康儿童和青少年（男性175名；平均年龄7.49±3.57岁；平均BMI 17.94±4.1kg/m²）进行CIMT评估。他们根据年龄分为3组：第一组（GI），1至5岁[n = 93名（33.2%）；男性57名；平均BMI 16±3kg/m²]；第二组（GII），6至10岁[n = 127名（45.4%）；男性78名；平均BMI 17.9±3.7kg/m²]；第三组（GIII），11至15岁[n = 60名（21.4%）；男性40名；平均BMI 20.9±4.5kg/m²]。
儿童和青少年男性与女性之间的CIMT值无显著差异（分别为0.43±0.06mm和0.42±0.05mm；p = 0.243）。根据Pearson相关系数，CIMT在总体人群中以及在3个年龄组中均与BMI无相关性。11至15岁的受试者CIMT值最高（GI与GII相比，p = 0.615；GI与GIII相比，p = 0.02；GII与GIII相比，p = 0.004）。
10岁以下的健康儿童，无论性别或BMI如何，CIMT都是恒定的。CIMT在10岁以后增加。
