Gossa Al-Saadde Dhiaa Lattef, Haider Ali Murtaza, Ali Arsalan, Abdu Musad Saleh Ebraheem, Turki Jalil Abduladheem, Abdulelah Furqan M, Romero-Parra Rosario Mireya, Tayyib Nahla A, Ramírez-Coronel Andrés Alexis, Alkhayyat Ameer S
Department of Internal Medicine, College of Medicine, Basrah University Teaching Hospital, Basrah, Iraq.
Faisalabad Medical University, Faisalabad, Pakistan.
Heliyon. 2023 Sep 4;9(9):e19826. doi: 10.1016/j.heliyon.2023.e19826. eCollection 2023 Sep.
In the recent years, micronutrients play an important role in improving body health with preventing and treating of chronic diseases. Chromium is one of the vital minerals involved in the regulation of insulin action. According to abundant evidences this mineral seems to be an essential factor involved in the reduction of insulin resistance and decreasing the risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs). Moreover, it has been proposed that Chromium supplementation affects mechanisms involved in blood pressure, lipid metabolism, inflammation, and oxidative stress. For instance, it may affect blood pressure through alteration of the renin-angiotensin system, as well as reducing the angiotensin-converting enzyme activity. Furthermore, Chromium supplementation might help coronary . This study aims to provide a comprehensive review regarding to the effects of Chromium supplementation on CVDs risk factors with an emphasis on possible molecular mechanisms.
近年来，微量营养素在促进身体健康以及预防和治疗慢性病方面发挥着重要作用。铬是参与调节胰岛素作用的重要矿物质之一。大量证据表明，这种矿物质似乎是降低胰岛素抵抗、降低2型糖尿病（T2DM）和心血管疾病（CVDs）风险的关键因素。此外，有人提出补充铬会影响与血压、脂质代谢、炎症和氧化应激相关的机制。例如，它可能通过改变肾素-血管紧张素系统来影响血压，同时降低血管紧张素转换酶的活性。此外，补充铬可能有助于改善冠状动脉情况。本研究旨在全面综述补充铬对心血管疾病风险因素的影响，并重点关注可能的分子机制。
