Urbanowicz Tomasz, Hanć Anetta, Frąckowiak Julia, Białasik-Misiorny Maksymilian, Radek Zofia, Krama Marta, Filipiak Krzysztof J, Krasińska-Płachta Aleksandra, Iwańczyk Sylwia, Kowalewski Mariusz, Tykarski Andrzej, Jemielity Marek
Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Thoracic Research Centre, Collegium Medicum Nicolaus Copernicus University, Innovative Medical Forum, 85-094 Bydgoszcz, Poland.
J Clin Med. 2024 Sep 5;13(17):5260. doi: 10.3390/jcm13175260.
: Multiple risk factors for coronary artery disease have been identified without answering one of the leading questions related to the extent of the involvement of the epicardial arteries. Trace elements are involved in various stages of atherosclerotic lesion formation and may play a significant role in the advancement of coronary artery disease. : A total of 157 (92 (59%) men and 65 (41%) women) patients with a median age of 71 (65-75) years presenting with chronic coronary syndrome were enrolled in the prospective single-center analysis. The coronary angiography results were compared with the concentration of trace elements in scalp hair. : Through Spearman analysis, a positive correlation between the number of diseased coronary arteries and hair trace element concentration was found for sodium (r = 0.198, = 0.013), vanadium (r = 0.164, = 0.040), chromium (r = 0.242, = 0.002), and nickel (r = 0.176, = 0.026). A negative relationship was noted between magnesium (r = -0.237, = 0.003) and calcium (r = -0.217, = 0.007) and the extent of epicardial lesions. : Scalp hair trace element analysis indicates the possible modulatory role of trace elements in advancing coronary artery disease. Since a significant correlation with one- and two-vessel but not with three-vessel disease was noted, it might be considered an "all or nothing" phenomenon. A positive correlation between the number of diseased coronary arteries and sodium, vanadium, chromium, and nickel and an inverse correlation with magnesium and calcium were noted. The presented analysis is hypothesis-generating, and further studies are necessary to corroborate the results from a clinical perspective.
已经确定了冠状动脉疾病的多种危险因素，但尚未回答与心外膜动脉受累程度相关的主要问题之一。微量元素参与动脉粥样硬化病变形成的各个阶段，并可能在冠状动脉疾病的进展中发挥重要作用。
共有157例（92例（59%）男性和65例（41%）女性）年龄中位数为71（65 - 75）岁的慢性冠状动脉综合征患者纳入了前瞻性单中心分析。将冠状动脉造影结果与头皮头发中的微量元素浓度进行比较。
通过Spearman分析，发现患病冠状动脉数量与头发微量元素浓度之间存在正相关的元素有钠（r = 0.198，P = 0.013）、钒（r = 0.164，P = 0.040）、铬（r = 0.242，P = 0.002）和镍（r = 0.176，P = 0.026）。而镁（r = -0.237，P = 0.003）和钙（r = -0.217，P = 0.007）与心外膜病变程度呈负相关。
头皮头发微量元素分析表明微量元素在冠状动脉疾病进展中可能具有调节作用。由于发现与单支和双支血管病变有显著相关性，而与三支血管病变无相关性，这可能被认为是一种“全或无”现象。注意到患病冠状动脉数量与钠、钒、铬和镍呈正相关，与镁和钙呈负相关。本分析只是提出假设，有必要进一步开展研究从临床角度证实这些结果。
