Satta M, Peana A, Sparatore A, Alamanni M C
Farmaco Sci. 1986 Sep;41(9):722-8.
Five 1-lupinyl-3R'-6R"-quinoxalin-2(1H)-ones were tested in mice for acute toxicity, explorative activity inhibition, analgesic activity and for antagonism against physostigmine, strychnine and pentylentetrazol (cardiazol). As reference compounds were used chloropromazine, morphine, atropine and diazepam respectively. All tested compounds inhibit the explorative activity and exhibit high analgesic activity. Compound (I) protects completely the animals from physostigmine toxicity, while compound (IV) antagonizes, although only slightly, all the toxicants tested.
对5种1-鲁平基-3R'-6R"-喹喔啉-2(1H)-酮在小鼠中进行了急性毒性、探索性活动抑制、镇痛活性以及对毒扁豆碱、士的宁和戊四氮（卡地阿唑）的拮抗作用测试。分别使用氯丙嗪、吗啡、阿托品和地西泮作为参考化合物。所有测试化合物均抑制探索性活动并表现出高镇痛活性。化合物（I）可使动物完全免受毒扁豆碱毒性影响，而化合物（IV）对所有测试毒物均有拮抗作用，尽管作用轻微。
