Sparatore A, Boido-Canu C, Sparatore F, Manca P, Satta M
Farmaco Sci. 1985 May;40(5):303-14.
Fifteen N-lupinyl derivatives of 3-methyl-, 3-phenyl- and 3-benzylquinoxalin-2(1H)-one, variously substituted on position 6 (R = CH3O, CH3, Cl, CF3), were prepared. Of these, all 1-lupinyl-3-methylquinoxalin-2-ones exhibit a high degree of deconditioning activity in the tests of acquisition and modification of a conditioned avoidance response (C.A.R.) in rats. In both tests, compounds (II) and (IV), with R = CH3O and Cl respectively, proved more active than chloropromazine.
制备了3-甲基-、3-苯基-和3-苄基喹喔啉-2(1H)-酮的15种N-羽扇豆酰衍生物，它们在6位有不同取代（R = CH3O、CH3、Cl、CF3）。其中，所有1-羽扇豆酰-3-甲基喹喔啉-2-酮在大鼠条件性回避反应（C.A.R.）的习得和改变测试中均表现出高度的去条件化活性。在这两个测试中，R分别为CH3O和Cl的化合物（II）和（IV）比氯丙嗪更具活性。
