新京都啡肽，一种从人肺癌中分离出的镇痛肽。

Neo-kyotorphin, an analgesic peptide isolated from human lung carcinoma.

作者信息

Zhu Y X, Hsi K L, Chen Z G, Zhang H L, Wu S X, Zhang S Y, Fang P F, Guo S Y, Kao Y S, Tsou K

出版信息

FEBS Lett. 1986 Nov 24;208(2):253-7. doi: 10.1016/0014-5793(86)81027-4.

Abstract

A pentapeptide with analgesic activity has been isolated from human lung squamous cell carcinoma and from three other types of propagated tumors of human lung small-cell carcinoma (SCC), adenoma (AD) and large-cell carcinoma (LCC) in nude mice. The amino acid sequence of the peptide has been revealed to be H-Thr-Ser-Lys-Tyr-Arg-OH, which is exactly the same as that of neo-kyotorphin, an analgesic peptide originally isolated from bovine brain [(1982) Life Sci. 31, 1733]. No neo-kyotorphin could be isolated from normal lung tissue using the same procedures as those used for carcinomas. The results suggest that the presence of neo-kyotorphin in the lung carcinoma may represent the ectopic expression of peptide hormone. Our findings constitute the first example of a human lung carcinoma producing analgesic peptide.

摘要

一种具有镇痛活性的五肽已从人肺鳞状细胞癌以及裸鼠体内三种其他类型的人肺肿瘤（小细胞癌、腺瘤和大细胞癌）中分离出来。该肽的氨基酸序列已被确定为H-Thr-Ser-Lys-Tyr-Arg-OH，与最初从牛脑中分离出的镇痛肽新脑啡肽完全相同[(1982)生命科学31, 1733]。使用与癌组织相同的程序，无法从正常肺组织中分离出新脑啡肽。结果表明，肺癌中存在新脑啡肽可能代表肽激素的异位表达。我们的发现构成了人类肺癌产生镇痛肽的首个实例。